Design, Synthesis, and Application of a Type of Chiral Spirocyclic Naphthylamines.

Abstract read

In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ronghua ZhangDepartment of Chemistry and the Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration & Reconstruction, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR 999077, China.ORCID 0000-0001-9279-8790

Minghui ZhuDepartment of Chemistry and the Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration & Reconstruction, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR 999077, China.

Jianwei SunDepartment of Chemistry and the Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration & Reconstruction, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR 999077, China.ORCID 0000-0002-2470-1077

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A family of new spirocyclic chiral mono- and diamine structures has been designed together with their de novo asymmetric synthesis, featuring a short sequence from simple substrates. This study complements the previous limited exploration of the counterparts of well-established 1,1'-spirobiindane-7,7'-diol (SPINOL) and its modified analogs. The convenient enantioselective synthesis of 2,2',3,3'-tetrahydro-1,1'-spirobi-[phenalene]-9,9'-diamine (SPHENAM) and 9'-amino-2,2',3,3'-tetrahydro-1,1'-spirobi[phenalen]-9-ol (NOSPHEN) represents a notable advantage over the limited spirocyclic precedents of this type, which were uniformly derived from their spiro parents. Two synthetic routes, both featuring catalyst-controlled enantioselective induction, have been designed, leading to the convenient construction of a large library of both

Identifiers

PMID41021776

DOI10.1021/jacs.5c12568

PMCPMC12512103

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.