Evidence map›Paper›PMID 41021693›Full record

ArticleAmerican journal of physiology. Cell physiology2025

Connexin-hemichannels-mediated ATP release causes lung injury following chlorine inhalation.

Ahmed Lazrak, Zhihong Yu, Sadis Matalon

Abstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ahmed LazrakDivision of Molecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine, Pulmonary Injury and Repair Center, Heersinck School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0002-4127-1937
Zhihong YuDivision of Molecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine, Pulmonary Injury and Repair Center, Heersinck School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Sadis MatalonDivision of Molecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine, Pulmonary Injury and Repair Center, Heersinck School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0003-0683-3700

Funding

PATHOPHYSIOLOGY OF SUBLETHAL OXYGEN IN INJURED LUNGSR01HL031197 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MARK N GILLESPIE, Sadis Matalon · 1985 to 2026
$4.2M
Mitigation of Chlorine Injury to MitochondriaR21ES032956 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MATALON, SADIS · 2021 to 2022
$422k
Mechanisms and countermeasures of halogen-induced injury to pregnant miceR21ES026829 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JILLING, TAMAS SANDOR, MATALON, SADIS · 2015 to 2015
$351k
HHS | National Institutes of Health (NIH) 3 R01HH031197-29S1HHS | National Institutes of Health (NIH) 5-R01HH031197-30HHS | National Institutes of Health (NIH) 5R21ES032956NHLBI NIH HHS R01 HL031197NIEHS NIH HHS R21 ES026829NIEHS NIH HHS R21 ES032956University of Alabama at Birmingham (UAB) ReInvent Grant
6 · The paper itself

Abstract

Chlorine (Cl

Indexed as

Acute Lung InjuryAdenosine TriphosphateChlorineConnexinsLungLung InjuryAdministration, InhalationAnimalsBronchoalveolar Lavage FluidHumansInhalation ExposureMaleMiceMice, Inbred C57BLAdenosine TriphosphateChlorineConnexinsalveolar edemaATPchlorineconnexin-hemichannelslung edema

Identifiers

PMID41021693
PMCPMC12548752

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.