Evidence map›Paper›PMID 41021670›Full record

ReviewCirculation2025

Targeting Calcium Regulation for Heart Failure and Arrhythmia Therapeutics: A Critical Review.

Gabriel Redel-Traub, Steven O Marx, Andrew R Marks

Abstract readReview
In one paragraph

Review in Circulation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Gabriel Redel-TraubDepartment of Medicine (G.R.-T., S.O.M.), Columbia University, New York, NY.ORCID 0000-0003-0908-7889
Steven O MarxDepartment of Medicine (G.R.-T., S.O.M.), Columbia University, New York, NY.ORCID 0000-0002-0577-6030
Andrew R MarksPhysiology and Cellular Biophysics (S.O.M., A.R.M.), Columbia University, New York, NY.ORCID 0000-0002-8057-1502

Funding

POSTDOCTORAL TRAINING IN ARTERIOSCLEROSIS RESEARCHT32HL007343 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI HENRY N GINSBERG, Muredach P Reilly · 1985 to 2026
$12.7M
Structure-Function of Calcium Channel Complexes in Cardiac Physiology and DiseaseP01HL164319 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Henry M. Colecraft · 2023 to 2026
$12.1M
L-type channel trafficking and modulation in heartR01HL121253 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Henry M. Colecraft, Steven O Marx · 2014 to 2026
$8.4M
Exploring the Molecular Physiology of Atrial FibrillationR01HL140934 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT, MARX, STEVEN O · 2018 to 2025
$6.0M
Phosphorylation-dependent regulation of calcium channels by macromolecular complexesR01HL146149 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Steven O Marx, Geoffrey S Pitt · 2019 to 2026
$5.0M
Investigating Cardiac Ion Channels by Novel MethodsR01HL155377 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Steven O Marx · 2021 to 2026
$3.8M
Structure-function analysis for elucidating pathogenicity of cardiac ryanodine receptor genetic variantsR01HL145473 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT, SHEPARD, KENNETH L · 2019 to 2022
$3.1M
Calcium and the Pathophysiology of Neurodegenerative DisordersRF1NS114570 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT · 2020 to 2020
$2.3M
Calcium and the physiology of diabetesR01DK118240 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT · 2019 to 2022
$1.6M
Novel Therapeutic Approaches to Atrial Fibrillation Targeting Intracellular CalciR01HL102040 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT · 2011 to 2014
$1.6M
Calcium and the Pathophysiology of Neurodegenerative DisordersR01NS114570 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT · 2024 to 2024
$571k
NHLBI NIH HHS P01 HL164319NHLBI NIH HHS R01 HL102040NHLBI NIH HHS R01 HL121253NHLBI NIH HHS R01 HL140934NHLBI NIH HHS R01 HL145473NHLBI NIH HHS R01 HL146149NHLBI NIH HHS R01 HL155377NHLBI NIH HHS T32 HL007343NIDDK NIH HHS R01 DK118240NINDS NIH HHS R01 NS114570NINDS NIH HHS RF1 NS114570
6 · The paper itself

Abstract

Despite advances in pharmacologic and procedural therapies, heart failure (HF) and cardiac arrhythmias remain significant global health burdens, highlighting the urgent need for novel therapeutic strategies. Defective Ca

Indexed as

Anti-Arrhythmia AgentsArrhythmias, CardiacCalciumCalcium SignalingHeart FailureAnimalsHumansMyocytes, CardiacAnti-Arrhythmia AgentsCalciumarrhythmias, cardiaccalcium signalingdrug therapyheart failureryanodine receptor calcium release channelsarcoplasmic reticulum calcium-transporting ATPases

Identifiers

PMID41021670
PMCPMC12554249

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.