ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2025
Association between ultra-short heart rate variability and risk of Parkinson's disease: a prospective cohort study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
backgroundCross-sectional studies have suggested that patients with Parkinson's disease (PD) have significantly lower heart rate variability (HRV) than healthy controls. However, the role of ultra-short HRV (usHRV) as an early biomarker for PD remains unclear. The objective of this study was to investigate the association between usHRV and PD risk and its underlying mechanisms.
methodsIn a prospective cohort study based on the UK Biobank, participants without PD and dementia at baseline who had available 15-second resting electrocardiogram data (n = 48 202) were included. The participants were followed up for an average of 12.24 years, and some were diagnosed with PD (n = 307). Cox proportional hazards models were used to examine the association between usHRV parameters and PD risk. A nested case-control study was conducted within the cohort to further investigate temporal trends in HRV. Mediation analysis was used to explore the underlying mechanisms driven by brain structure, peripheral inflammation, and proteomic biomarkers.
resultsWe found that lower usHRV parameters were significantly associated with an increased PD risk. Notably, an L-shaped association was observed between the corrected root mean square of successive differences and PD risk. Temporal trend analysis suggested usHRV levels of patients with PD started to decline approximately 10 years before diagnosis. Mediation analysis revealed that thalamus-related fiber tracts, plasma inflammatory, and neuroendocrine markers mediated the association between usHRV and PD risk.
conclusionsOur findings provide evidence supporting that usHRV may serve as an early, convenient, and noninvasive biomarker of PD risk up to a decade before diagnosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.