Trial reportDigestive diseases (Basel, Switzerland)2025
Bowel Preparation for Colonoscopy: The Patient Point of View.
Trial report in Digestive diseases (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
6 authors.
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Abstract
introductionColonoscopy is a common procedure that requires adequate bowel preparation. Polyethylene glycol (PEG) is widely used but commonly associated with patient complaints, including the split-dose administration schedule. Mannitol could be an attractive alternative as it acts quickly, requires low volumes, and is palatable. A recent Phase III international, multicenter, randomized study (SATISFACTION) compared the efficacy and safety of bowel preparation using same-day oral mannitol or a split-dose regimen of 2L PEG-ASC. This study investigated the effects of the two laxatives on the Bowel Cleansing Impact Review (BOCLIR), a questionnaire exploring the degree of satisfaction of patients undergoing preparation for a colonoscopy.
methodsThe BOCLIR measures the acceptability and tolerability of bowel cleansers on three unidimensional scales (satisfaction, symptoms, and activity limitations). The total score is the sum of the three sub-scores and ranges from 0 to 110, with higher scores representing worse patient experiences.
resultsThis analysis included 476 patients who completed the BOCLIR questionnaire: 236 in the mannitol group and 240 in the PEG-ASC group. The difference in the least square means of the total score was -8.01 (95% CI: -10.70 to -5.31), with a highly significant difference in favor of mannitol (p < 0.0001).
conclusionThis analysis of the SATISFACTION study shows that bowel preparation with mannitol was far preferable to PEG-ASC in terms of acceptability and tolerability. Based on these results, mannitol may be close to an ideal preparation from the patient's point of view.
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