Evidence map›Paper›PMID 41021357›Full record

ArticleAging cell2025

Vascular Endothelial NAMPT-Mediated NAD

Shotaro Kosugi, Shintaro Yamaguchi, Ken Nishioka, Taichi Nagahisa, Yasuhiro Watanabe, Daiki Kojima, Kenji Kaneko, Ryunosuke Mitsuno, Ran Nakamichi, Yoshinaga Kawano and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Shotaro KosugiDivision of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Shintaro YamaguchiDivision of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.ORCID 0000-0002-4917-033X
Ken NishiokaDivision of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Taichi NagahisaDivision of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Yasuhiro WatanabeDivision of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Daiki KojimaDivision of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.ORCID 0000-0003-2906-676X
Kenji KanekoDivision of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Ryunosuke MitsunoDivision of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Ran NakamichiDivision of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Yoshinaga KawanoDivision of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Kenichiro KinouchiDivision of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Koichiro HommaDepartment of Emergency and Critical Care Medicine, Keio University School of Medicine, Tokyo, Japan.ORCID 0000-0001-5223-9599
Takeshi KandaDivision of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Junichiro IrieDivision of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Kazutoshi MiyashitaDivision of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Toshiaki MonkawaMedical Education Center, Keio University School of Medicine, Tokyo, Japan.
Jun YoshinoDivision of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Hiroshi ItohDivision of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Kaori HayashiDivision of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.

Funding

Daiwa Securities Health FoundationJapan Arteriosclerosis Prevention FundJapan Diabetes Society Junior Scientist Development Grant supported by Novo Nordisk Pharma Ltd. 2019-2020JSPS KAKENHI 21K07377JSPS KAKENHI 25K10691JSPS KAKENHI 25K10721Takeda Science Foundation
6 · The paper itself

Abstract

Aging is associated with metabolic dysfunction and cardiovascular abnormalities. Defective nicotinamide adenine dinucleotide (NAD

Indexed as

CytokinesEndothelial CellsNADNeovascularization, PhysiologicNicotinamide PhosphoribosyltransferaseAngiogenesisAnimalsMaleMiceMice, Inbred C57BLMice, KnockoutNicotinamide MononucleotideNitric Oxide Synthase Type IIISirtuin 1CytokinesNADNicotinamide MononucleotideNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, mouseNitric Oxide Synthase Type IIISirtuin 1agingangiogenesisglucose metabolismhypertensionNAMPT‐mediated NAD+ biosynthesisvascular endothelial cell

Identifiers

PMID41021357
PMCPMC12608088

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.