Evidence map›Paper›PMID 41021219›Full record

ArticleJournal of women's health (2002)2026

Adverse Pregnancy Outcomes and Cognitive Change in Older Women.

Laura B Harrington, Sarah E Tom, Chloe Krakauer, Paige D Wartko, Kristi Chau, Roxanne Muiruri, Elizabeth Micks, Linda K McEvoy, Andrea Z LaCroix, Eliza C Miller

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of women's health (2002), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Laura B HarringtonKaiser Permanente Washington Health Research Institute, Seattle, Washington, USA.
Sarah E TomDepartment of Neurology, Columbia University, New York, New York, USA.
Chloe KrakauerKaiser Permanente Washington Health Research Institute, Seattle, Washington, USA.
Paige D WartkoKaiser Permanente Washington Health Research Institute, Seattle, Washington, USA.
Kristi ChauDepartment of Neurology, Columbia University, New York, New York, USA.
Roxanne MuiruriKaiser Permanente Washington Health Research Institute, Seattle, Washington, USA.
Elizabeth MicksDepartment of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA.
Linda K McEvoyKaiser Permanente Washington Health Research Institute, Seattle, Washington, USA.
Andrea Z LaCroixHerbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, California, USA.
Eliza C MillerDepartment of Neurology, Columbia University, New York, New York, USA.ORCID 0000-0002-7108-8906

Funding

Translational pharmacoepidemiology: neuroprotection and neurotoxicity of antihypertensives and strong anticholinergicsU19AG066567 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI Christine L MacDonald · 2021 to 2026
$80.4M
Furthering scientific understanding of mechanisms underlying resilience to the effects of AD pathology by incorporating state of the art quantification of gliosis, inflammation, & synaptic toxicityU01AG006781 · NIA · UNIVERSITY OF WASHINGTON · PI CRANE, PAUL K, LARSON, ERIC B · 1986 to 2020
$39.3M
Neurovascular Unit Dysfunction in Women with Severe PreeclampsiaK23NS107645 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MILLER, ELIZA C · 2019 to 2023
$1.1M
Pregnancy complications and the development of Alzheimer's disease and related dementias in women in the Adult Changes in Thought studyR21AG069111 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MILLER, ELIZA C · 2020 to 2021
$460k
NIA NIH HHS R21 AG069111NIA NIH HHS U01 AG006781NIA NIH HHS U19 AG066567NINDS NIH HHS K23 NS107645
6 · The paper itself

Abstract

introductionWhether the history of adverse pregnancy outcomes (APOs) contributes to cognitive decline in women is unclear.

methodsAmong parous female Adult Changes in Thought (ACT) participants (aged ≥ 65 years without dementia at enrollment), we abstracted APO history for those born 1940 or later and enrolled between 2005 and 2020 (

resultsAmong all participants, 13% had a history of APO. In adjusted models, women with an APO history had 0.23-point lower CASI-IRT score at any age (95% confidence interval: -0.54, 0.07); this small difference was not statistically significant. We found no evidence of an association between APO history and 4-year cognitive change.

conclusionAmong women in the ACT study born in 1940 or later, we found no evidence of a significant association between history of APO and lower cognition or cognitive decline in older adulthood.

Indexed as

CognitionCognitive DysfunctionPregnancy ComplicationsPregnancy OutcomeAgedAged, 80 and overFemaleHumansPregnancyadverse pregnancy outcomescognitioncognitive declinehypertensive disorders of pregnancymaternalpreeclampsiapregnancypreterm birth

Identifiers

PMID41021219
PMCPMC12865798

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.