ArticleCerebellum (London, England)2025
Lateral Cerebellar Theta Burst Stimulation Can Modulate Default Mode Network Connectivity in Autistic Adults.
Article in Cerebellum (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Applications and potential mechanisms of transcranial magnetic stimulation in autism spectrum disorders.Journal of translational medicine · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Developing effective neuromodulation strategies for core autistic symptoms remains a critical need. The lateral cerebellum, implicated in socio-cognitive functions often affected in autism, represents a promising target for repetitive transcranial magnetic stimulation (rTMS), which has not yet been tested in this population. Here, we report a pilot investigation of the safety, feasibility, and network-level effects of one-session intermittent theta burst stimulation (iTBS, a variant of rTMS; 1200 pulses delivered at 80% active motor threshold with a 15-minute inter-train interval) targeting the right lateral cerebellum (Crus I/II) in 10 autistic adults (7 assigned male, 3 assigned female at birth, aged 19-30 years). All participants tolerated the protocol well, with no severe adverse events and a 100% retention rate. Resting-state functional MRI indicated a significant post-iTBS decrease in functional connectivity within the default-mode network and somatosensory motor network, while other networks remained unchanged. Moreover, idiosyncrasy in functional connectivity within the ventral attention, frontoparietal, default-mode and visual networks significantly decreased after iTBS. These findings suggest that cerebellar iTBS is safe and feasible for autistic adults and may acutely modulate multiple large-scale functional networks in their brain. Future multi-session, sham-controlled trials are warranted to validate these results and investigate whether repeated cerebellar stimulation yields sustained neurobiological or clinical benefits in autism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.