ArticleDiscover oncology2025
Identification and prognostic significance of Ki-67-related genes in triple negative breast cancer.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThis study was aimed to screen and validate key genes associated with Ki-67 expression and evaluate their prognostic significance in patients with triple-negative breast cancer (TNBC). METHODS AND
resultsRNA sequencing data and clinical characteristics were obtained from the Fudan University Shanghai Cancer Center (FUSCC) database. A Cox regression model and bioinformatic analyses were employed to identify Ki-67-related prognostic genes. Candidate genes were further validated using the Kaplan-Meier Plotter database and patient specimens from our medical center. A total of 241 differentially expressed genes between high and low Ki-67 expression groups were initially identified through Gene Ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment. Further analysis revealed that CCNA2, a Ki-67-related gene, was an independent risk factor for overall survival. Patients with high-risk scores exhibited significantly higher mortality rates than those with low-risk scores. Moreover, immunohistochemistry analysis showed that high CCNA2 protein expression was significantly associated with histological grade and recurrence or metastasis within 3 years after surgery (all P < 0.05).
conclusionsCCNA2 overexpression may contribute to tumorigenesis and serve as a potential prognostic biomarker indicating poor outcomes in TNBC.
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