ArticleJapanese journal of ophthalmology2026
Role of perfusion-related metrics in visual field progression of primary open-angle and exfoliation glaucoma: a natural language processing approach.
Article in Japanese journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Effects of relative humidity on intraocular pressure using a time-series analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
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6 authors.
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Abstract
purposeTo investigate the association between vascular factors affecting optic nerve perfusion and glaucoma progression in a clinical setting with systematic monitoring of blood pressure and intraocular pressure (IOP). STUDY
designRetrospective cohort study.
methodsThis retrospective study analyzed 428 primary open-angle glaucoma (POAG; n=295) and exfoliation glaucoma (EXG; n=133) patients from Shimane University Hospital. We employed a validated Bidirectional Encoder Representations from Transformers (BERT)-based natural language processing system to extract clinical data from electronic medical records of 36,561 visits, including blood pressure measurements, IOP, and medication details across 216 clinical parameters. Mixed-effects regression models were employed to identify factors associated with visual field mean deviation (MD) and the rate of MD decline.
resultsThe cohort demonstrated consistent pressure management (median IOP: 13.0 mmHg; median systolic: 138.0 mmHg; median diastolic: 79.0 mmHg). Ocular perfusion pressure (OPP) showed no significant association with either visual field MD or the rate of MD decline. Significant predictors of worse visual field MD included age (coefficient: -0.28, 95% CI -0.33 to -0.23, p<0.001), history of filtration surgery (coefficient: -3.8, 95% CI -5.7 to -1.9, p<0.001), and number of glaucoma medications (coefficient: -0.19, 95% CI -0.35 to -0.030, p=0.020). Factors significantly associated with faster MD decline were age, initial MD severity, and medication burden.
conclusionsIn a clinical setting with systematic monitoring, OPP provided limited prognostic value for glaucoma progression, while traditional clinical factors were stronger predictors. Our BERT-based approach demonstrates how artificial intelligence (AI)-powered data extraction enables comprehensive analyses of clinical records, offering new insights for routine ophthalmological care.
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