ArticleAlcohol, clinical & experimental research2025
Early alcohol abstinence symptoms and the role of cumulative adversity.
Article in Alcohol, clinical & experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Perceived Social Support Moderates the Response to Stress and Alcohol Cues During Early Abstinence From Alcohol.Biological psychiatry global open science · 2026Article
- Early alcohol abstinence symptoms and the role of cumulative adversity.Alcohol, clinical & experimental research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundThis study examined the course of early alcohol abstinence symptoms across multiple clinical domains (i.e., cravings, withdrawal, mood, and cardiovascular measures) in individuals undergoing inpatient alcohol treatment and assessed whether cumulative lifetime adversity influences the severity and trajectory of these symptoms.
methodsResearchers tracked withdrawal symptoms, alcohol cravings, mood states, heart rate, and blood pressure in 34 inpatient participants at treatment admission and weekly for three to four consecutive weeks. The analysis employed two approaches: first, examining symptom presentation and progression over time in alcohol-dependent individuals using cumulative adversity as a moderating variable; second, comparing symptom patterns between alcohol-dependent participants with high versus low lifetime adversity against 38 control participants at each timepoint.
resultsAbstinence symptoms resolved by the third week of inpatient treatment across all participants. However, alcohol-dependent individuals with greater lifetime adversity exhibited significantly more severe symptom patterns compared to alcohol-dependent individuals with fewer adverse experiences. These differences persisted even when controlling for recent alcohol and tobacco use severity over the preceding 3 months.
conclusionsUnderstanding the profile and progression of early abstinence symptoms, along with stress-related moderating factors, could inform more personalized care planning. Cumulative lifetime adversity may serve as a readily measurable correlate of early abstinence severity and may be valuable for predicting alcohol treatment outcomes. Addressing the effects of cumulative lifetime adversity may serve as a target for early intervention in patients with alcohol use disorder.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.