Evidence map›Paper›PMID 41021106›Full record

ArticleClinical oral investigations2025

Identification and characterization of salivary immune complex antigens in oral cancer.

Maria Sei, Sayo Kanda, Nozomi Aibara, Rean Hashimura, Junya Hashizume, Yuki Jimbayashi Kutsuna, Tomofumi Naruse, Keisuke Omori, Hironori Sakai, Shin-Ichi Yamada and 12 more

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Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Maria Sei *Department of Pharmacy Practice, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Sayo Kanda *Department of Pharmacy Practice, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Nozomi AibaraDepartment of Pharmacy Practice, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Rean HashimuraDepartment of Pharmacy Practice, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Junya HashizumeDepartment of Hospital Pharmacy, Nagasaki University Hospital, Nagasaki University, Nagasaki, Japan.
Yuki Jimbayashi KutsunaDepartment of Pharmacy Practice, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Tomofumi NaruseDepartment of Oral and Maxillofacial Surgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Keisuke OmoriDepartment of Oral and Maxillofacial Surgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Hironori SakaiDepartment of Dentistry and Oral Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
Shin-Ichi YamadaDepartment of Oral and Maxillofacial Surgery, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan.
Takumi HasegawaDepartment of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Daisuke TakedaDepartment of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Nobuhiro YamakawaDepartment of Oral and Maxillofacial Surgery, School of Medicine, Nara Medical University, Kashihara, Japan.
Tadaaki KiritaDepartment of Oral and Maxillofacial Surgery, School of Medicine, Nara Medical University, Kashihara, Japan.
Tomoaki KurosakiDepartment of Pharmacy Practice, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Hirotaka MiyamotoDepartment of Pharmaceutics, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Kayoko SatoDepartment of Hospital Pharmacy, Nagasaki University Hospital, Nagasaki University, Nagasaki, Japan.
Yukinobu KodamaDepartment of Hospital Pharmacy, Nagasaki University Hospital, Nagasaki University, Nagasaki, Japan.
Mihoko N NakashimaDivision of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan.
Mikiro NakashimaDepartment of Pharmacy Practice, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Souichi YanamotoDepartment of Oral Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, 734-8553, Japan. syana@hiroshima-u.ac.jp.
Kaname OhyamaDepartment of Hospital Pharmacy, Nagasaki University Hospital, Nagasaki University, Nagasaki, Japan. k-ohyama@nagasaki-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aims to identify antigens incorporated into immune complexes that are associated with oral cancer pathogenesis and to determine their potential clinical applications. MATERIALS AND

methodsIn this study, immune complexome analysis was performed on saliva samples from 66 patients with oral cancer and 40 controls. Immune complexome analysis is an original method for the comprehensive identification of immune complex antigens in body fluids by liquid chromatography-mass spectrometry.

resultsWe identified 24 IC-antigens that were significantly elevated in early-stage oral cancer compared with the controls, suggesting their potential as indicators for oral cancer. Four IC-antigens (ALOX5, B3GALT6, LAMA4, POLA1) were expressed at significantly higher levels in advanced-stage disease, indicating their involvement in cancer progression. Survival analysis revealed that high levels of POLA1 were associated with lower survival rates. Most of these proteins were reported to be involved in cancer progression and cell proliferation.

conclusionThese findings support the formation of disease-characteristic immune complexes in oral cancer and highlight the potential of immune complexome analysis in saliva for understanding oral cancer pathogenesis and therapeutic targets.

Indexed as

Antigen-Antibody ComplexMouth NeoplasmsSalivaAdultAgedBiomarkers, TumorCase-Control StudiesChromatography, LiquidFemaleHumansMaleMass SpectrometryMiddle AgedNeoplasm StagingAntigen-Antibody ComplexBiomarkers, TumorAntigenC1q ELISAImmune complexMass spectrometryOral cancer

Identifiers

PMID41021106

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.