Evidence map›Paper›PMID 41021098›Full record

ArticleVeterinary research communications2025

Feasibility and safety of intrathecal transplantation of allogeneic bone marrow mesenchymal stem cells in horses.

Lucas Vinícius de Oliveira Ferreira, Leandro Maia, Danielle Jaqueta Barberini, Regina Kiomi Takahira, Vânia Maria de Vasconcelos Machado, Gisele Fabrino Machado, Guilherme Dias de Melo, Rogério Martins Amorim

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Article in Veterinary research communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lucas Vinícius de Oliveira FerreiraDepartment of Veterinary Clinic, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-8835-9736
Leandro MaiaDepartment of Veterinary Clinic, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
Danielle Jaqueta BarberiniDepartment of Veterinary Clinic, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
Regina Kiomi TakahiraDepartment of Veterinary Clinic, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.ORCID http://orcid.org/0000-0003-3323-4199
Vânia Maria de Vasconcelos MachadoDepartment of Veterinary Surgery and Animal Reproduction, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-9057-5793
Gisele Fabrino MachadoDepartment of Clinic, Surgery and Animal Reproduction, São Paulo State University (UNESP), Araçatuba, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-7701-6375
Guilherme Dias de MeloDepartment of Clinic, Surgery and Animal Reproduction, São Paulo State University (UNESP), Araçatuba, São Paulo, Brazil.ORCID http://orcid.org/0000-0003-0747-7760
Rogério Martins AmorimDepartment of Veterinary Clinic, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil. rogerio.amorim@unesp.br.ORCID http://orcid.org/0000-0003-3750-5857

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) have emerged as a promising alternative for treating neurological disorders due to their neuroprotective, neuroregenerative, immunomodulatory, anti-inflammatory, and anti-apoptotic properties. The use of allogeneic MSCs offers advantages such as the selection of specific cells and their immediate availability. This study aimed to evaluate the safety and feasibility of intrathecal transplantation of allogeneic equine bone marrow-derived MSCs (EqBM-MSCs) in healthy horses. Ten healthy horses (five-12 years old) were randomly divided into two groups. In the control group (n = 5), phosphate-buffered saline was administered intrathecally, while the MSCs group (n = 5) received 3 × 10

Indexed as

Mesenchymal Stem Cell TransplantationAnimalsFeasibility StudiesFemaleHorsesInjections, SpinalMagnetic Resonance ImagingMaleMesenchymal Stem CellsTransplantation, HomologousCell-based therapyCerebrospinal fluidEquineMatrix metalloproteinaseNeurology

Identifiers

PMID41021098

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.