ArticleMolecular biology reports2025
Effects of dopamine on the proliferation and osteo/odontogenic differentiation of stem cells of the apical papilla.
Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Aptamer-Directed Porous DNA Nanocomposite Hydrogel for Active Pulp Preservation: Immunomodulation, Stem Cell Recruitment and Reparative Dentinogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStem cells derived from the apical papilla of teeth (SCAPs) have the potential to proliferate and differentiate into osteogenic and odontoblastic lineages. However, limited information is available on the effect of osteogenic environments containing dopamine on these cells. METHODS AND
resultsThis experimental laboratory study used SCAPs extracted from the pulp of third molar teeth of individuals aged 18 years. SCAPs were treated with dopamine at doses of 1, 10, 100, 1000, and 2000 μM for different treatment periods (24, 48, and 72 h). No treatment was performed for the control group. Cell viability and proliferation were assessed using the MTT (Methyl Thiazolyl Tetrazolium) assay, osteogenic differentiation was evaluated using Alizarin Red S (ARS) staining, and gene expression of bone-related markers was analyzed using reverse transcription polymerase chain reaction (RT-PCR). Data analysis was performed using SPSS software (version 18), and comparisons between groups were made using t-tests and ANOVA. After 24, 48, and 72 h, no significant difference was observed between the dopamine-treated and control groups in terms of SCAP viability/proliferation at low concentrations. However, a significant reduction in cell viability was observed at high dopamine concentrations (2000 μM). ARS staining indicated that dopamine treatment enhanced osteogenic differentiation of SCAPs. Gene expression analysis following dopamine treatment showed an increase in osteogenic/odontogenic markers in SCAPs, including alkaline phosphatase (ALP), dentin sialophosphoprotein (DSPP), dentin matrix protein-1 (DMP-1), and bone sialoprotein (BSP) (P < 0.05).
conclusionDopamine influenced SCAP viability in a dose- and time-dependent manner, leading to osteogenic/odontogenic differentiation and increased expression of differentiation-related genes. These findings suggest that dopamine can act as a potential bioactive molecule in regenerative endodontic therapies.
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