Evidence map›Paper›PMID 41021035›Full record

ArticleCancer immunology, immunotherapy : CII2025

The protective role of γδ T cells in endometrial cancer.

David P Mysona, Akash Shah, Natalia Jaeger, Ahmad Almadadi, Brian Orr, Richard McIndoe, Marian Johnson, Robert Higgins, Bunja Rungruang, Sharad Ghamande and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

David P MysonaDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Medical College of Georgia, 1120 15th Street, Augusta, GA, 30912, USA. mysona@musc.edu.
Akash ShahDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Medical College of Georgia, 1120 15th Street, Augusta, GA, 30912, USA.
Natalia JaegerImmunology Center of Georgia, Augusta University, 1410 Laney Walker Blvd, Augusta, GA, 30912, USA.
Ahmad AlmadadiImmunology Center of Georgia, Augusta University, 1410 Laney Walker Blvd, Augusta, GA, 30912, USA.
Brian OrrDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC, 29425, USA.
Richard McIndoeCenter for Biotechnology and Genomic Medicine, Augusta University, 1120 15th Street, Augusta, GA, 30912, USA.
Marian JohnsonDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Medical College of Georgia, 1120 15th Street, Augusta, GA, 30912, USA.
Robert HigginsDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Medical College of Georgia, 1120 15th Street, Augusta, GA, 30912, USA.
Bunja RungruangDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Medical College of Georgia, 1120 15th Street, Augusta, GA, 30912, USA.
Sharad GhamandeDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Medical College of Georgia, 1120 15th Street, Augusta, GA, 30912, USA.
Catherine HedrickImmunology Center of Georgia, Augusta University, 1410 Laney Walker Blvd, Augusta, GA, 30912, USA.
Klaus LeyImmunology Center of Georgia, Augusta University, 1410 Laney Walker Blvd, Augusta, GA, 30912, USA.

Funding

Vascular macrophages and T cells in atherosclerosisR35HL145241 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI LEY, KLAUS F. · 2019 to 2025
$5.9M
NHLBI NIH HHS R35 HL145241
6 · The paper itself

Abstract

Γδ T cells are non-conventional T cells that are not MHC restricted and have T cell receptors (TCRs) that are stimulated by phosphoantigens, stress-induced proteins, lipids, and other antigens. These cells are prognostic across cancer types in The Cancer Genome Atlas (TCGA) but have not been well studied in endometrial cancer, which has a rising incidence and mortality rate. Endometrial cancer patients have variable responses to checkpoint inhibitors which are related to the molecular subtype of their cancer. As such, there is a pressing need to understand the immune microenvironment in endometrial cancer. This study addresses this gap in knowledge by investigating γδ T cell repertoires and transcriptomes in this disease site. γδ T cell repertoires were obtained for 543 endometrial cancer patients within the TCGA and from 5 endometrial cancer patients in the single cell dataset SRP349751 using TRUST4. GLIPH2 was used to identify TCRs predicted to bind the same antigen. Transcriptomes were investigated in the single cell dataset. DNA Polymerase Epsilon Exonuclease (POLE) and Microsatellite Instability High (MSI-H) endometrial cancer subtypes had the most γδ T cell infiltration. Vδ1 and Vδ3 γδ T cell infiltration was prognostic independent of stage and molecular subtype. GLIPH2 analysis revealed TCRδ motifs for TDK, YTD, and GEL were public across all four molecular subtypes and were present in the single cell data set. Vδ1 γδ T cell transcriptomes were associated with cytotoxicity and recent TCR stimulation. These data support further investigation of immunotherapies targeting γδ T cells in endometrial cancer.

Indexed as

Endometrial NeoplasmsLymphocytes, Tumor-InfiltratingReceptors, Antigen, T-Cell, gamma-deltaFemaleHumansPrognosisTranscriptomeTumor MicroenvironmentReceptors, Antigen, T-Cell, gamma-deltaEndometrial CancerImmune MicroenvironmentImmunologyLymphocyteNon Conventional T cells

Identifiers

PMID41021035
PMCPMC12480308

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.