ArticleCancer immunology, immunotherapy : CII2025
Stress induces corticosterone-mediated CD8
Article in Cancer immunology, immunotherapy : CII, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Cancer Neuroscience: From Local Neuro-Immune Microenvironments to Systemic Brain-Body Circuitry.MedComm · 2026Review
- Neural regulation in lung cancer: from mechanisms to new therapeutic perspectives.Clinical and experimental medicine · 2026Review
- Multiscale systems modelling of communication networks in brain metastasis.Experimental & molecular medicine · 2026Review
- Stress-Related Immunomodulation of Canine Lymphocyte Responses and Hematologic Profiles.International journal of molecular sciences · 2026Article
- Emotional distress is associated with neuroendocrine-immune remodeling and less favorable neoadjuvant immunotherapy outcomes in oral squamous cell carcinoma.Frontiers in immunology · 2026Article
- The neural niche in cancer: mechanistic insights into tumor-neuron-immune crosstalk and therapeutic opportunities.Frontiers in cell and developmental biology · 2026Review
- Neural regulation of lung cancer: from mechanisms to clinical implications.European journal of medical research · 2025Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundPsychological stress can affect the incidence and mortality of non-small cell lung cancer. However, how stress influenced tumor immunity, especially tumor-infiltrating CD8
methodsWe constructed anxiety-like model with acute restraint stress and evaluated behaviors of mice through open-field test, light-dark box test and forced swimming test. Flow cytometry was performed to detect the proportion of immune cells in tumor tissues, immunofluorescence to explore the expression of related proteins, smart RNA sequence and qRT-PCR to monitor the relative genes in RNA levels, and ELISA to measure hormone concentrations in mouse serum.
resultsWe observed that acute restraint stress can cause anxiety-like behaviors in mice and promote the progression of non-small cell lung cancer. Stress suppressed the expression of TNF-α, IFN-γ, granzyme B and Ki67, and induced an upregulation of PD-1
conclusionsIn brief, our study demonstrates that stress-corticosterone axis induces exhaustion of tumor-infiltrating CD8
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Registered trials
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