Evidence map›Paper›PMID 41020940›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Felcisetrag stimulates 5-HT

Lina Maria Rayo Abella, Joachim Neumann, Britt Hofmann, Uwe Kirchhefer, Ulrich Gergs

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Prokinetic drugs that stimulate 5-HTNaunyn-Schmiedeberg's archives of pharmacology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lina Maria Rayo AbellaInstitute for Pharmacology and Toxicology, Medical Faculty, Martin-Luther-University Halle-Wittenberg, Magdeburger Straße 4, D-06097, Halle (Saale), Germany.
Joachim NeumannInstitute for Pharmacology and Toxicology, Medical Faculty, Martin-Luther-University Halle-Wittenberg, Magdeburger Straße 4, D-06097, Halle (Saale), Germany. joachim.neumann@medizin.uni-halle.de.
Britt HofmannDepartment of Cardiac Surgery, Mid-German Heart Centre, University Hospital Halle, Ernst-Grube Straße 40, D-06097, Halle (Saale), Germany.
Uwe KirchheferInstitute for Pharmacology and Toxicology, Medical Faculty, University Münster, Domagkstraße 12, D-48149, Munster, Germany.
Ulrich GergsInstitute for Pharmacology and Toxicology, Medical Faculty, Martin-Luther-University Halle-Wittenberg, Magdeburger Straße 4, D-06097, Halle (Saale), Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Felcisetrag (methyl 4-[[4-[[(2-propan-2-yl-1H-benzimidazole-4-carbonyl)-amino]-methyl]-piperidin-1-yl]methyl]piperidine-1-carboxylate, TD-8954, TAK-954) has a structural formula with similarity to serotonin. It is one of the most potent compounds to bind to recombinant human 5-HT

Indexed as

BenzimidazolesHeart AtriaPiperidinesReceptors, Serotonin, 5-HT4Serotonin 5-HT4 Receptor AgonistsAnimalsFemaleHumansMaleMiceMice, TransgenicMyocardial ContractionSerotonin 5-HT4 Receptor AntagonistsBenzimidazolesPiperidinesReceptors, Serotonin, 5-HT4Serotonin 5-HT4 Receptor AgonistsSerotonin 5-HT4 Receptor Antagonists5-HT4-serotonin receptorsFelcisetragHuman atriumMouse atriumTransgenic mice

Identifiers

PMID41020940
PMCPMC12935854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.