Nickel oxide modified with sodium alginate and dopamine nanoparticles for enhanced antimicrobial, antioxidant, and anticancer activity against HepG2 cells.

Marupati Siddhartha, Shruti Ahlawat, Chandra Prabha Sahu, Gopidesi Radha Krishna, Indumathi Thangavelu, Srinivas Tadepalli, Ahmed A Bhran

Abstract read

PubMed Publisher

In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marupati SiddharthaDepartment of Chemistry, Vardhaman College of Engineering, Hyderabad, India.

Shruti AhlawatDepartment of Life Sciences, Faculty of Allied Health Sciences, SGT University, Gurugram, Haryana, India.

Chandra Prabha SahuDepartment of Electrical & Electronics, ARKA JAIN University, Jamshedpur, Jharkhand, India.

Gopidesi Radha KrishnaDepartment of Mechanical Engineering, Presidency University, Bengaluru, Karnataka, India.

Indumathi ThangaveluDepartment of Chemistry, CHRIST (Deemed to Be University), Bangalore, Karnataka, 560029, India.

Srinivas TadepalliDepartment of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Kingdom of Saudi Arabia. stadepalli@imamu.edu.sa.

Ahmed A BhranDepartment of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Kingdom of Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, while multidrug-resistant bacterial infections pose escalating health threats. To address these challenges, nickel oxide nanoparticles (NiO Nanoparticles) and sodium alginate-dopamine-NiO-SA-Dop nanoparticles (NiO-SA-Dop Nanoparticles) were synthesized and extensively characterized for multifunctional biomedical applications. X-ray diffraction revealed crystallite sizes of 40.6 nm (NiO) and 29.76 nm (NiO-SA-Dop). Transmission electron microscope analysis confirmed spherical morphology with reduced particle size upon modification, supporting improved surface properties. UV-visible spectroscopy showed band gap energies of 4.15 eV (NiO) and 4.44 eV (NiO-SA-Dop). Photoluminescence spectra indicated enhanced green emission in NiO-SA-Dop, suggesting a higher concentration of oxygen vacancies Linked to increased reactive oxygen species Generation. In functional assays, NiO-SA-Dop demonstrated superior free radical scavenging efficiency in the 2,2-diphenyl-1-picrylhydrazyl assay compared to NiO. Strong antibacterial activity was observed against Gram-negative pathogens including Pseudomonas aeruginosa, Klebsiella pneumoniae, Vibrio cholerae, Escherichia coli, and Shigella dysenteriae. Cytotoxicity assays against HepG2 cells yielded IC₅₀ values of 11.9 µg/mL for NiO and 10.3 µg/mL for NiO-SA-Dop, underscoring the enhanced anticancer efficacy of the modified nanoparticles. Overall, NiO-SA-Dop Nanoparticles exhibit promising antibacterial, antioxidant, and anticancer activities, making them strong candidates for advanced therapeutic development.

Indexed as

AlginatesAnti-Bacterial AgentsAnti-Infective AgentsAntineoplastic AgentsAntioxidantsDopamineNanoparticlesNickelCell SurvivalHep G2 CellsHumansMicrobial Sensitivity TestsAlginatesAnti-Bacterial AgentsAnti-Infective AgentsAntineoplastic AgentsAntioxidantsDopamineNickelnickel monoxideAntibacterial activityCancer therapyCytotoxicity – HepG2 cellsDPPH radical scavengingNiONiO-SA-DopReactive oxygen species

Identifiers

PMID41020939

DOI10.1007/s00210-025-04607-9

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.