ReviewDiscover oncology2025
Firmicutes in gut microbiota: hormonal influence on breast cancer in obese individuals.
Review in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Dance and Dietary Intervention Improves Metabolic Health, Fitness, and Quality of Life With Modest Gut Microbiota Shifts in Breast Cancer Patients With Obesity: A Pilot RCT.Cancer reports (Hoboken, N.J.) · 2026Trial
- Gut Microbiota Metabolic Reprogramming Drives Endocrine and Immune Resistance in Hormone-Dependent Cancers.Cancers · 2026Review
- Diet, the Gut Microbiome, and Estrogen Physiology: A Review in Menopausal Health and Interventions.Nutrients · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Breast cancer (BC) is among the leading causes of death in women. The risk factors of BC are various, among which obesity has been proved to be closely related to the incidence and progression of BC, especially in postmenopausal women. Obesity leads to elevated estrogen levels, increased inflammatory factors, and insulin resistance, which are considered to increase the risk of BC. Microbial dysbiosis has emerged as an important element in the development and progression of various cancers, including BC. Meanwhile, Firmicutes, a phylum enriched in the gut microbiota, can affect the metabolism of estrogen and progesterone, which explains part of its role in promoting the development of BC. This review highlights the "obesity-microbiota-hormone-breast cancer" axis, focusing on Firmicutes influence on BC in hormone levels. We also explore potential methods to prevent obesity-related BC and improve patient survival outcomes by regulating gut microbiota. To identify relevant studies, we conducted a comprehensive literature search in PubMed, Web of Science, and Scopus up to April 2025 using a combination of MeSH terms and free-text keywords related to obesity, microbiota, hormones, and BC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.