ReviewMolecular biology reports2025
Unveiling the Spatiotemporal dynamics of stress granule phase transition: A key mechanism governing neuronal fate in acute ischemic stroke.
Review in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
Funding
Abstract
Acute Ischemic Stroke, as a cerebrovascular disease with high mortality and disability rates worldwide, has a complex pathological mechanism and a narrow therapeutic window. After the onset of ischemia, the ischemic core area of the brain tissue rapidly infarcts due to irreversible damage, while the fate of neurons in the surrounding penumbra depends on the dynamic balance between stress adaptation and cumulative damage. In recent years, stress granules, key structures that enable cells to respond to stress, have become a focus of research regarding their dynamic phase transitions (liquid-liquid phase separation and liquid-solid phase separation) and their role in regulating neuronal fate. This article systematically reviews the biological characteristics of stress granules, their spatiotemporal dynamic patterns in Acute Ischemic Stroke, and their association with neuronal damage. Also, it explores potential therapeutic strategies targeting stress granules.
Indexed as
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41020925What OpenQuestion holds
Registered trials
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