Evidence map›Paper›PMID 41020885›Full record

ArticleCurrent issues in molecular biology2025

Uncovering the Tumorigenic Blueprint of PFOS and PFOA Through Multi-Organ Transcriptomic Analysis of Biomarkers, Mechanisms, and Therapeutic Targets.

Krisha Mathur, Aleezah Khaliq, Stephanie Park, Nathan Chu, Vaishnavi M Burra, Norah Kanukolanu, Ellen Costello, Sivanesan Dakshanamurthy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current issues in molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Krisha MathurThe School of Humanities, Arts, and Social Sciences, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
Aleezah KhaliqCollege of Computer, Mathematical, and Natural Sciences, University of Maryland, College Park, MD 20742, USA.
Stephanie ParkCollege of Arts and Sciences, Georgetown University, Washington, DC 20057, USA.
Nathan ChuDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA.
Vaishnavi M BurraDepartment of Biology, School of Arts & Sciences, College of William and Mary, Williamsburg, VA 23185, USA.ORCID 0009-0007-2797-0292
Norah KanukolanuDepartment of Biology, Boston College, Chestnut Hill, MA 02467, USA.ORCID 0009-0006-2076-9986
Ellen CostelloDepartment of Biological Sciences, College of Science, University of Notre Dame, Notre Dame, IN 46556, USA.
Sivanesan DakshanamurthyDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC 20007, USA.ORCID 0000-0003-3681-4121

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Per- and polyfluoroalkyl substances (PFASs), called forever chemicals, persist in the environment and bioaccumulate, posing significant health risks. While epidemiological studies have linked exposure to specific PFAS types, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS), to an increased incidence of various cancers, specific tumorigenesis mechanisms are unknown. Here, we investigated the potential molecular markers and signatures of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) tumorigenesis. We performed a comprehensive transcriptomic analysis across multiple species and tissue types (

Indexed as

cancer preventive therapeuticscarcinogenesismechanismsper- and polyfluoroalkyl substancesPFOAPFOStranscriptomicstumor biomarkerstumorigenesis

Identifiers

PMID41020885
PMCPMC12468109

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.