Evidence map›Paper›PMID 41020883›Full record

ArticleCurrent issues in molecular biology2025

Comparative Molecular Profiling and Bioactivity Analysis of Algerian Propolis: Antioxidant, Antibacterial Activities, and In Silico NRF2-KEAP1 Pathway Modulation.

Amel Reguig, Ahmed Messai, Ibtissam Kahina Bedaida, Diana C G A Pinto, Chawki Bensouici, Abdelmoneim Tarek Ouamane, Artur M S Silva, Jean-Philippe Roy

Abstract read
In one paragraph

Article in Current issues in molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amel ReguigDEDSPAZA Laboratory, Department of Agronomical Sciences, Faculty of Exact Sciences and Natural and Life Sciences, University of Biskra, Biskra 07000, Algeria.ORCID 0009-0001-5593-2126
Ahmed MessaiPIARA Laboratory, Department of Agronomical Sciences, Faculty of Exact Sciences and Natural and Life Sciences, University of Biskra, Biskra 07000, Algeria.ORCID 0000-0002-1509-5319
Ibtissam Kahina BedaidaLaboratory of Biotechnology of Bioactive Molecules and Cellular Physiopathology (LBMBPC), Faculty of Natural and Life Sciences, University of Batna 2, Batna 05000, Algeria.ORCID 0000-0002-1694-3551
Diana C G A PintoLAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0003-4249-7089
Chawki BensouiciNational Center for Biotechnological Research (CRBT), BP E73 Ali Mendjili, Constantine 25000, Algeria.ORCID 0000-0003-4612-4642
Abdelmoneim Tarek OuamaneCenter for Scientific and Technical Research on Arid Regions (CRSTRA), Biskra 07000, Algeria.ORCID 0000-0002-7723-6834
Artur M S SilvaLAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0003-2861-8286
Jean-Philippe RoyDepartment of Clinical Sciences, Université de Montréal, Saint-Hyacinthe, QC J2S 2M2, Canada.ORCID 0000-0002-0444-2303

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Propolis, a natural bee-derived product rich in diverse phytochemicals with potential therapeutic benefits, remains underexplored in Algeria. This study investigated the molecular profile, antioxidant capacity, and antibacterial activity of propolis sourced from two bioclimatically distinct Algerian regions (humid subtropical Batna and hot desert Biskra) using electrospray ionization mass spectrometry, ultra-high-performance liquid chromatography with diode array detection, and gas chromatography-mass spectrometry. Significant regional variations were observed, with propolis extract 2 (PE2) exhibiting a higher bioactive content, including a constituent not previously reported in propolis. Antioxidant assays (2,2-diphenyl-1-picrylhydrazyl, 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid), ferric reducing antioxidant power, and phenanthroline) demonstrated that PE2 consistently outperformed propolis extract 1 and the reference standards (DPPH IC

Indexed as

ADME-Toxbee productcharacterizationGC-MSmolecular dockingUHPLC-DAD-ESI/MS

Identifiers

PMID41020883
PMCPMC12468889

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.