Evidence map›Paper›PMID 41020877›Full record

ArticleCurrent issues in molecular biology2025

Checkpoint-Dependent Sensitivities to Nucleoside Analogues Uncover Specific Patterns of Genomic Instability.

Zainab Burhanuddin Kagalwala, Mohammed Ayan Chhipa, Zohreh Kianfard, Essam Karam, Sirasie P Magalage, Sarah A Sabatinos

Abstract read
In one paragraph

Article in Current issues in molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zainab Burhanuddin KagalwalaDepartment of Chemistry and Biology, Faculty of Science, Toronto Metropolitan University, Toronto, ON M5B 2K3, Canada.
Mohammed Ayan ChhipaDepartment of Chemistry and Biology, Faculty of Science, Toronto Metropolitan University, Toronto, ON M5B 2K3, Canada.
Zohreh KianfardDepartment of Chemistry and Biology, Faculty of Science, Toronto Metropolitan University, Toronto, ON M5B 2K3, Canada.
Essam KaramDepartment of Chemistry and Biology, Faculty of Science, Toronto Metropolitan University, Toronto, ON M5B 2K3, Canada.
Sirasie P MagalageDepartment of Chemistry and Biology, Faculty of Science, Toronto Metropolitan University, Toronto, ON M5B 2K3, Canada.
Sarah A SabatinosDepartment of Chemistry and Biology, Faculty of Science, Toronto Metropolitan University, Toronto, ON M5B 2K3, Canada.ORCID 0000-0002-0685-7668

Funding

Natural Sciences and Engineering Research Council RGPIN-2015-04405Toronto Metropolitan University Faculty of Science Dean's Research FundsToronto Metropolitan University StartupUniversity College London Pharmacy International (TMU)
6 · The paper itself

Abstract

Nucleoside analogues are used as drugs and as labels in laboratory-based research. However, the effect of different nucleoside analogue mechanism(s) on cell sensitivity or mutagenesis is unclear. This is particularly important in cancer treatments where checkpoint proteins and DNA damage factors are often mutated. We tested six nucleoside analogues in fission yeast,

Indexed as

cell cycle checkpointDNA damage and repairDNA replication instabilityfission yeast screengenome instabilityhalf-maximal inhibitory concentration (IC50)HIV anti-retrovirusnucleoside analoguesynthetic lethality

Identifiers

PMID41020877
PMCPMC12468036

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.