Evidence map›Paper›PMID 41020717›Full record

ReviewDNA and cell biology2025

Nucleosome Linker Length and Distribution as Major Players in Epigenetic Regulation: Insights from Cryo-Electron Microscopy and Modeling of Retina Cell Maturation.

Tamar Schlick, Sergei Grigoryev

Abstract readReview
In one paragraph

Review in DNA and cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tamar SchlickDepartment of Chemistry and Courant Institute of Mathematical Sciences, and Simons Center for Computational Physical Chemistry, New York University; and NYU-ECNU Center for Computational Chemistry, NYU Shanghai, Shanghai, China.ORCID 0000-0002-2392-2062
Sergei GrigoryevDepartment of Molecular and Precision Medicine, Penn State University College of Medicine, Hershey, Pennsylvania, United States.

Funding

Bridging Disparate Structural/Functional Scales: Multiscale Modeling of the Chromatin Fiber and RNA Tertiary StructuresR35GM122562 · NIGMS · NEW YORK UNIVERSITY · PI Tamar Schlick · 2017 to 2026
$4.6M
Nanoscale cryo-electron tomographic analysis of nucleosome condensates in neuronal chromatinR21DA056343 · NIDA · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GRIGORYEV, SERGEI A · 2022 to 2023
$455k
NIDA NIH HHS R21 DA056343NIGMS NIH HHS R35 GM122562
6 · The paper itself

Abstract

We summarize recent findings on the conformational differences of chromatin fibers in immature versus mature retina cells due to different nucleosome linker length values and distributions, as revealed by cryo-electron microscopy and modeling studies, emphasizing implications to chromatin organization and epigenetic regulation broadly.

Indexed as

Epigenesis, GeneticNucleosomesRetinaAnimalsChromatinCryoelectron MicroscopyHumansChromatinNucleosomeschromatincryo-EMepigenetic regulationlinker DNA lengthmesoscale modelingretina cells

Identifiers

PMID41020717
PMCPMC12725084

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.