Evidence map›Paper›PMID 41020695›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

CDH1 Orchestrates Anabolic Events to Promote Cell Cycle Initiation.

Yun-Zi Mao, Jiao-Jiao Zhang, Meng-Qi You, Han Wang, Yan Lin, Yuan Fang, Hui-Lu Zhang, Yuan-Yuan Qu, Qian Zhou, Meng Wang and 9 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07450833 (Assessing the Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07450833 phase1completednot on this map

Assessing the Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers - An Open Label, Phase I Study

TypeinterventionalSponsorBenfovir AGRan2022 to 2022Enrolled48ConditionsHealthy VolunteersArmsBenfo-oxythiamine
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. CDH1 Orchestrates Anabolic Events to Promote Cell Cycle Initiation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Yun-Zi MaoThe Obstetrics and Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Shanghai Key Laboratory of Metabolic Remodeling and Health, State Key Laboratory of Genetics and Development of Complex Phenotypes, and Institutes of Biomedical Sciences, Fudan Unviersity, Shanghai, 200433, China.
Jiao-Jiao ZhangThe Obstetrics and Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Shanghai Key Laboratory of Metabolic Remodeling and Health, State Key Laboratory of Genetics and Development of Complex Phenotypes, and Institutes of Biomedical Sciences, Fudan Unviersity, Shanghai, 200433, China.
Meng-Qi YouThe Obstetrics and Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Shanghai Key Laboratory of Metabolic Remodeling and Health, State Key Laboratory of Genetics and Development of Complex Phenotypes, and Institutes of Biomedical Sciences, Fudan Unviersity, Shanghai, 200433, China.
Han WangThe Obstetrics and Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Shanghai Key Laboratory of Metabolic Remodeling and Health, State Key Laboratory of Genetics and Development of Complex Phenotypes, and Institutes of Biomedical Sciences, Fudan Unviersity, Shanghai, 200433, China.
Yan LinThe Obstetrics and Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Shanghai Key Laboratory of Metabolic Remodeling and Health, State Key Laboratory of Genetics and Development of Complex Phenotypes, and Institutes of Biomedical Sciences, Fudan Unviersity, Shanghai, 200433, China.
Yuan FangDepartment of Liver Surgery, Zhongshan Hospital of Fudan University, Shanghai, 200032, China.
Hui-Lu ZhangDepartment of Digestive Diseases, Huashan Hospital of Fudan University, Shanghai, 200040, China.
Yuan-Yuan QuDepartment of Urology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, China.
Qian ZhouDepartment of Urology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, China.
Meng WangThe Obstetrics and Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Shanghai Key Laboratory of Metabolic Remodeling and Health, State Key Laboratory of Genetics and Development of Complex Phenotypes, and Institutes of Biomedical Sciences, Fudan Unviersity, Shanghai, 200433, China.
Gang LiThe Obstetrics and Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Shanghai Key Laboratory of Metabolic Remodeling and Health, State Key Laboratory of Genetics and Development of Complex Phenotypes, and Institutes of Biomedical Sciences, Fudan Unviersity, Shanghai, 200433, China.
Zi-Fan GuoThe Obstetrics and Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Shanghai Key Laboratory of Metabolic Remodeling and Health, State Key Laboratory of Genetics and Development of Complex Phenotypes, and Institutes of Biomedical Sciences, Fudan Unviersity, Shanghai, 200433, China.
Meng XuThe Obstetrics and Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Shanghai Key Laboratory of Metabolic Remodeling and Health, State Key Laboratory of Genetics and Development of Complex Phenotypes, and Institutes of Biomedical Sciences, Fudan Unviersity, Shanghai, 200433, China.
Jie LiuDepartment of Digestive Diseases, Huashan Hospital of Fudan University, Shanghai, 200040, China.
Peng-Cheng LinKey Laboratory for Tibet Plateau Phytochemistry of Qinghai Province, College of Pharmacy, Qinghai University for Nationalities, Xining, 810007, China.
Yi-Yuan YuanThe Obstetrics and Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Shanghai Key Laboratory of Metabolic Remodeling and Health, State Key Laboratory of Genetics and Development of Complex Phenotypes, and Institutes of Biomedical Sciences, Fudan Unviersity, Shanghai, 200433, China.
Yu KangThe Obstetrics and Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Shanghai Key Laboratory of Metabolic Remodeling and Health, State Key Laboratory of Genetics and Development of Complex Phenotypes, and Institutes of Biomedical Sciences, Fudan Unviersity, Shanghai, 200433, China.
Shi-Min ZhaoThe Obstetrics and Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Shanghai Key Laboratory of Metabolic Remodeling and Health, State Key Laboratory of Genetics and Development of Complex Phenotypes, and Institutes of Biomedical Sciences, Fudan Unviersity, Shanghai, 200433, China.ORCID https://orcid.org/0000-0003-4285-9801
Wei XuThe Obstetrics and Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Shanghai Key Laboratory of Metabolic Remodeling and Health, State Key Laboratory of Genetics and Development of Complex Phenotypes, and Institutes of Biomedical Sciences, Fudan Unviersity, Shanghai, 200433, China.

Funding

National Key R&D Program of China 2024YFA1306002National Key R&D Program of China 2024YFA1802700National Key R&D Program of China 2024YFA1803504National Science Foundation of China 32171298National Science Foundation of China 32230054National Science Foundation of China 32400635National Science Foundation of China 32400647National Science Foundation of China 82171672National Science Foundation of China 92253305National Science Foundation of China 92357301Postdoctoral Fellowship Program of CPSF GZB20250637Qinghai Province Resource Platform 2024-ZJ-T02Sanming Project of Medicine in Shenzhen SZSM202311005
6 · The paper itself

Abstract

Cell proliferation requires anabolic supports. How the cell cycle integrates anabolism remains poorly understood. Herein, it is identified that G1-phase regulator cell division cycle 20-like protein 1 (CDH1) coordinates anabolic events to ensure cell cycle initiation. CDH1 degrades Von Hippel-Lindau (VHL), concomitantly activates hypoxia-inducible factor 1α (HIF1α), which enhances angiogenesis and glucose metabolism, and activates mitochondrial lactyltransferase alanyl tRNA synthetase (AARS2), which lactylates and inactivates pyruvate dehydrogenase E1 subunit alpha 1 (PDHA1), thereby conserving anabolites. Among the CDH1-accumulated anabolites, ribose-5-phosphate (R5P) binds to transketolase-like-1 (TKTL1) to bridge CDH1 to cyclin-dependent kinase 2 (CDK2) and Skp1-Cullin-F-box and β-transducin repeat-containing protein (SCF

Indexed as

Antigens, CDCadherinsCdh1 ProteinsCell CycleAnimalsCell ProliferationHumansHypoxia-Inducible Factor 1, alpha SubunitMiceVon Hippel-Lindau Tumor Suppressor ProteinAntigens, CDCadherinsCDH1 protein, humanCdh1 ProteinsHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitVHL protein, humanVon Hippel-Lindau Tumor Suppressor ProteinanabolismCDH1cell cycleR5P

Identifiers

PMID41020695
PMCPMC12713023

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.