Evidence map›Paper›PMID 41020683›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Interfacial Coordination-Engineered Emulgel Modulates the Osteo-Immune Microenvironment in Periodontitis Treatment Via HIF1 Signaling Pathway-Induced Metabolic Reprogramming.

Hui Zhang, Xiao Huang, Rui Chen, Weimin Lin, Linke Li, Xi Peng, Xinxi Yang, Xingyu Chen, Tailin Guo, Jie Weng and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hui ZhangCollege of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, 610031, P. R. China.ORCID https://orcid.org/0000-0002-6905-3181
Xiao HuangCollege of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, 610031, P. R. China.
Rui ChenCollege of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, 610031, P. R. China.
Weimin LinState Key Laboratory of Oral Diseases and National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Chengdu, 610041, P. R. China.
Linke LiCollege of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, 610031, P. R. China.
Xi PengCollege of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, 610031, P. R. China.
Xinxi YangCollege of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, 610031, P. R. China.
Xingyu ChenCollege of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, 610031, P. R. China.
Tailin GuoCollege of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, 610031, P. R. China.
Jie WengCollege of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, 610031, P. R. China.
Jianshu LiCollege of Polymer Science and Engineering. State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610041, P. R. China.
Quan YuanState Key Laboratory of Oral Diseases and National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Chengdu, 610041, P. R. China.
Huan TanCollege of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, 610031, P. R. China.
Mengyuan WangCollege of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, 610031, P. R. China.ORCID https://orcid.org/0000-0001-9869-6883

Funding

Chengdu Science and Technology Bureau project 2024-YF05-00178-SNChengdu Science and Technology Bureau project 2024-YF05-00183-SNFundamental Research Funds for the Central Universities 2682025ZTPY044National Natural Science Foundation of China 22172120National Natural Science Foundation of China 82101012Third People's Hospital of Chengdu Scientific Research Project 2023PI13Third People's Hospital of Chengdu Scientific Research Project CSY-YN-01-2023-014
6 · The paper itself

Abstract

A multifunctional high internal phase Pickering emulsion (HIPPE-QU) is developed to address immune dysregulation in periodontitis by reprogramming macrophage metabolism and promoting tissue regeneration. Fabricated via one-step homogenization, HIPPE-QU features a 75% internal phase and is co-stabilized by gelatin nanoparticles (GNPs) and copper-doped hydroxyapatite (HA-Cu), forming a gel-like, injectable emulgel suitable for clinical application. Hydrophobic quercetin (QU) is encapsulated in the internal phase and chelates with Cu

Indexed as

Hypoxia-Inducible Factor 1Hypoxia-Inducible Factor 1, alpha SubunitPeriodontitisAnimalsCellular MicroenvironmentGelatinHumansMacrophagesMetabolic ReprogrammingMiceNanoparticlesQuercetinSignal TransductionGelatinHypoxia-Inducible Factor 1Hypoxia-Inducible Factor 1, alpha SubunitQuercetinHIF‐1 signaling pathwayhigh internal phase pickering emulsionmacrophage polarizationmetabolic reprogrammingperiodontitisquercetin

Identifiers

PMID41020683
PMCPMC12697898

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.