Evidence map›Paper›PMID 41020661›Full record

Observational studyClinical transplantation2025

Impact of Donor and Recipient Sex on Long-Term Outcomes Following Living Donor Kidney Transplantation: A Retrospective Dual-Center Study.

Yitian Fang, Lisa B Westenberg, Julie J M Hamm, Jacqueline van de Wetering, Stephan J L Bakker, Ron W F de Bruin, Robert A Pol, Robert C Minnee

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Clinical transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yitian FangErasmus MC Transplant Institute, Department of Surgery, Division of HPB and Transplant Surgery, Erasmus Medical Center, Rotterdam, Netherlands.ORCID https://orcid.org/0000-0002-5523-9794
Lisa B WestenbergDivision of Transplantation Surgery, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Julie J M HammErasmus MC Transplant Institute, Department of Surgery, Division of HPB and Transplant Surgery, Erasmus Medical Center, Rotterdam, Netherlands.
Jacqueline van de WeteringErasmus MC Transplant Institute, University Medical Center Rotterdam, Department of Internal Medicine, Division of Nephrology and Transplantation, Rotterdam, Netherlands.
Stephan J L BakkerDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Ron W F de BruinErasmus MC Transplant Institute, Department of Surgery, Division of HPB and Transplant Surgery, Erasmus Medical Center, Rotterdam, Netherlands.
Robert A PolDivision of Transplantation Surgery, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Robert C MinneeErasmus MC Transplant Institute, Department of Surgery, Division of HPB and Transplant Surgery, Erasmus Medical Center, Rotterdam, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe impact of donor and recipient sex on living donor kidney transplantation (LDKT) remains debated. This study investigates the impact of donor-recipient sex combinations on long-term transplant outcomes.

methodsA dual-center retrospective study was conducted at Erasmus Medical Center (EMC) and University Medical Center Groningen (UMCG), including all LDKT patients between 2010 and 2020. Transplantations were categorized into male donor-male recipient (MDMR, n = 476), female donor-male recipient (FDMR, n = 765), male donor-female recipient (MDFR, n = 463), and female donor-female recipient pairs (FDFR, n = 372). The primary outcome was graft survival. Secondary outcomes included patient survival, delayed graft function (DGF), acute rejection, and graft function.

resultsThe 10-year death-censored graft survival rates were 85.5% (MDMR), 85.4% (FDMR), 82.8% (MDFR), and 81.8% (FDFR) (p = 0.38), while corresponding 10-year patient survival rates were 73.3%, 70.7%, 74.8%, and 73.6%, respectively (p = 0.28). Male recipients had a slightly higher DGF rate compared to females (6.9% vs. 5.6%, p = 0.29). The incidence of acute rejection ranged from 15.5% to 18.3% across all combinations (p = 0.76). FDFR pairs in recipients ≥ 60 years had significantly better graft survival (95.9% vs. 86.6% vs. 87.0% vs. 80.7%, p = 0.048). Cox regression model confirmed this protective effect of female donor kidneys in aged female recipients (adjusted HR 0.24, 95% CI: 0.06-0.91, p = 0.036). MDMR pairs consistently showed superior long-term graft function but this advantage did not translate into better graft survival.

conclusionsFemale recipients aged 60 or older benefit from improved graft survival when receiving female donor kidneys. While MDMR pairs consistently exhibited superior eGFR, this advantage did not translate into better graft survival.

Indexed as

Delayed Graft FunctionGraft RejectionKidney Failure, ChronicKidney TransplantationLiving DonorsPostoperative ComplicationsTransplant RecipientsAdultFemaleFollow-Up StudiesGlomerular Filtration RateGraft SurvivalHumansKidney Function TestsMaleMiddle Agedgraft survivalkidney transplantationliving donorsex

Identifiers

PMID41020661
PMCPMC12478291

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.