Evidence map›Paper›PMID 41020645›Full record

ArticleThe American journal of gastroenterology2026

Elevation of tTG-IgA Antibodies in a Prospective Cohort of Children at Risk of Celiac Disease: Insights From the CDGEMM Cohort.

Valentina Pucinischi, Victoria Kenyon, Monica Montuori, Pasqua Piemontese, Ruggiero Francavilla, Lorenzo Norsa, Giovanni Di Nardo, Maria Elisabetta Baldassarre, Maria Chiara Trovato, Michela Perrone and 11 more

Abstract read
In one paragraph

Article in The American journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Valentina PucinischiDepartment of Neurosciences, Mental Health and Sensory Organs (NESMOS), Sapienza University of Rome, Rome, Italy.
Victoria KenyonPediatric Gastroenterology & Nutrition, MassGeneral Hospital for Children, Boston, Massachusetts, USA.
Monica MontuoriMaternal and Child Health Department, Sapienza University of Rome, Rome, Italy.ORCID 0000-0003-2383-5177
Pasqua PiemonteseNICU, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.
Ruggiero FrancavillaInterdisciplinary Department of Medicine, Pediatric Section, Pediatric Hospital Giovanni XXIII, Bari, Italy.
Lorenzo NorsaPediatric Department, Children's Hospital Vittore Buzzi, University of Milan, Milan, Italy.ORCID 0000-0003-3322-2921
Giovanni Di NardoDepartment of Neurosciences, Mental Health and Sensory Organs (NESMOS), Sapienza University of Rome, Rome, Italy.ORCID 0000-0002-9026-7758
Maria Elisabetta BaldassarreSection of Neonatology and NICU, Interdisciplinary Department of Medicine, University of Bari "Aldo Moro", Bari, Italy.ORCID 0000-0003-0590-6664
Maria Chiara TrovatoUOS Riabilitazione Nutrizionale, UOC Gastroenterologia e Nutrizione, Ospedale Pediatrico Bambino Gesù, Rome, Italy.
Michela PerroneNICU, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.ORCID 0000-0002-1318-7922
Tiziana PassaroPediatrics-Cava de' Tirreni, Salerno University Hospital, Salerno, Italy.
Naire SansottaPediatric Hepatology, Gastroenterology and Transplantation Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.ORCID 0000-0002-8799-7266
Marco CroccoPediatric Gastroenterology and Endoscopy Unit, IRCCS Istituto Giannina Gaslini, Genova, Italy.ORCID 0000-0001-7277-4767
Annalisa MorelliDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", Pediatrics Section, University of Salerno, Baronissi, Italy.ORCID 0000-0002-9052-0266
Federica MalerbaPediatric Gastroenterology and Endoscopy Unit, IRCCS Istituto Giannina Gaslini, Genova, Italy.ORCID 0000-0002-9105-0630
Fernanda CristoforiInterdisciplinary Department of Medicine, Pediatric Section, Pediatric Hospital Giovanni XXIII, Bari, Italy.ORCID 0000-0001-5849-8110
Luca ElliCeliac Disease Referral Center, Ospedale Maggiore Policlinico, Milan, Italy.ORCID 0000-0002-0873-0759
Alessio FasanoPediatric Gastroenterology & Nutrition, MassGeneral Hospital for Children, Boston, Massachusetts, USA.ORCID 0000-0002-2134-0261
Francesco ValituttiEBRIS (European Biomedical Institute of Salerno), Salerno, Italy.ORCID 0000-0002-1473-2240
Maureen M LeonardPediatric Gastroenterology & Nutrition, MassGeneral Hospital for Children, Boston, Massachusetts, USA.ORCID 0000-0002-5955-5102
CDGEMM Team

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Takara Leah Stanley · 1994 to 2026
$31.6M
Prospective Multi-Omic Analysis of At-Risk infants to Model Celiac Disease PathogenesisK23DK122127 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI LEONARD, MAUREEN MICHELLE · 2019 to 2023
$1.2M
The Celiac Disease Genomic, Environmental, Microbiome, and Metabolomic (CD-GEMM) Prospective Cohort StudyR56AI169645 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI FASANO, ALESSIO · 2023 to 2023
$823k
The Celiac Disease Genome, Environment, Microbiome, and Metabolome (CD-GEMM) prospective cohort studyR56AI156711 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI FASANO, ALESSIO · 2021 to 2021
$410k
NIAID NIH HHS R56 AI156711NIAID NIH HHS R56 AI169645NIDDK NIH HHS 1R56AI169645NIDDK NIH HHS K23 DK122127NIDDK NIH HHS K23DK122127NIDDK NIH HHS P30 DK040561
6 · The paper itself

Abstract

Celiac disease (CeD) is a common immune-mediated condition that occurs in genetically predisposed individuals. In this study, we examined the trajectory of tissue transglutaminase IgA (tTG-IgA) antibodies in a prospective longitudinal cohort of over 500 children at risk of developing CeD due to having a first-degree relative with CeD. We identified 34 subjects from our cohort and examined tTG-IgA titers at seroconversion and 6 months before tTG-IgA seroconversion. We found that all subjects had normal tTG-IgA 6 months before seroconversion. Thus, we conclude that tTG-IgA elevation in subjects with CeD is a sudden event and its trajectory cannot be used as a marker to predict seroconversion in this population.

Indexed as

AutoantibodiesCeliac DiseaseGTP-Binding ProteinsImmunoglobulin ATransglutaminasesAdolescentBiomarkersChildChild, PreschoolFemaleHumansInfantLongitudinal StudiesMaleProspective StudiesProtein Glutamine gamma Glutamyltransferase 2AutoantibodiesBiomarkersGTP-Binding ProteinsImmunoglobulin AProtein Glutamine gamma Glutamyltransferase 2Transglutaminasesanti-transglutaminase antibodiesceliac diseasepotential celiac disease

Identifiers

PMID41020645
PMCPMC13037947

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.