ArticleCancer medicine2025
Explorative Detection of Fractional Exhaled Nitric Oxide (FeNO) in Exhaled Breath of Patients With Breast Cancer.
Article in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Unraveling role of arginine-NO metabolism by targeting HIF-1α signaling in mediating esophageal squamous cell carcinoma.Frontiers in molecular biosciences · 2026Article
- Explorative Detection of Fractional Exhaled Nitric Oxide (FeNO) in Exhaled Breath of Patients With Breast Cancer.Cancer medicine · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundNitric oxide (NO), a gaseous messenger with pleiotropic functions, plays a role in cancer, including breast cancer (BC). Considering the high permeability and leakiness of NO across tissues and the increased levels of NO recently reported in exhaled breath and blood of patients with lung cancer, we explored exhaled NO levels in patients with BC in a future perspective of non-invasive cancer detection. PATIENTS AND
methodsFractional exhaled NO (FeNO) levels were detected in the breath of 192 women with BC and malignancy-free controls employing a widely used point-of-care (POC)-based system previously developed for asthma monitoring.
resultsFeNO levels were lower in BC patients compared to controls, with the lowest levels in women with HER2-expressing tumors. In univariate and multivariate analyses and after adjustment for age, smoking, and asthma, this difference was not significant. The effects of smoking were not statistically significant, whereas asthmatic subjects had significantly higher levels of FeNO (p = 0.006). Neither menopause nor BMI had a significant impact on FeNO levels.
conclusionOur explorative work indicates that FeNO levels are heterogeneously detected in the breath of BC patients in the absence of confounding effects and are associated with the clinical characteristics of the disease. More sensitive detection of exhaled NO and larger cohorts enriched with ER negative BC are needed to further explore the potential of NO in non-invasive detection of BC, either alone or in conjunction with other BC-related volatile markers, and extending the NO measurement to blood or tissues.
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