Evidence map›Paper›PMID 41020555›Full record

ArticleInvestigative ophthalmology & visual science2025

Elevated Nasal-Temporal Asymmetry of the Choroidal Vascular Index in Pathologically Myopic Eyes.

Xuewen Ding, Yiyi Wang, Ni Wan, Xiaotian Wu, Jieying Shen, Haiyao Wang, Kuangching Lin, Hao Chen, Tong Wang, Ning Xu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Investigative ophthalmology & visual science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xuewen DingNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Yiyi WangNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Ni WanNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Xiaotian WuNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Jieying ShenNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Haiyao WangNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Kuangching LinNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Hao ChenNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Tong WangNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Ning XuNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Jinsong WangNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Meixiao ShenNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Yanfeng JiangNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Fan LuNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Yilei ShaoNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This study aimed to investigate regional variations in choroidal parameters and to assess whether intraocular symmetry can aid in identifying pathological myopia. Methods: Optical coherence tomography (OCT) images were analyzed from 53 eyes with non-high myopia (NHM), 30 eyes with simple high myopia (HM), and 29 eyes with pathological myopia (PM). Choroidal thickness (CT), luminal area (LA), stromal area (SA), and choroidal vascularity index (CVI) were measured within a 6 mm diameter macular region centered on the fovea. Intraocular symmetry of choroidal parameters was quantified by calculating absolute differences between the nasal and temporal, as well as the superior and inferior, regions. These measurements were combined with existing clinical data to help distinguish pathological myopia. Results: In the PM group, CT, LA, and SA were significantly reduced compared to both the HM and NHM groups (P < 0.001). The CVI in eyes with pathological myopia showed intergroup differences in certain areas when compared to eyes with NHM and/or simple HM. As myopia progresses, nasal-temporal CVI symmetry tends to increase in high myopia but decreases in pathological myopia. A model that included intraocular symmetry parameters demonstrated an impressive discriminative ability with an area under the curve value of 0.970 in distinguishing eyes with PM from those with HM. Conclusions: Our findings indicate that PM is characterized by topographical changes in CVI and a reduction in intraocular symmetry, which enhances its differentiation from simple HM.

Indexed as

ChoroidMyopiaMyopia, DegenerativeAdultFemaleHumansMaleMiddle AgedRetrospective StudiesTomography, Optical CoherenceYoung Adult

Identifiers

PMID41020555
PMCPMC12489860

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.