Evidence map›Paper›PMID 41020548›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2026

Lithium-Charged Gold Nanoparticles: A New Powerful Tool for Lithium Delivery and Modulation of Glycogen Synthase Kinase 3 Activity.

Antonio Buonerba, Giulia Puliatti, Domenica Donatella Li Puma, Bruno Bandiera, Beatrice Cannata, Maria Elena Marcocci, Nicolina Castagno, Irene Contento, Salvatore Impemba, Mariarosa Scognamiglio and 11 more

Abstract read
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Antonio BuonerbaDepartment of Chemistry and Biology "Adolfo Zambelli", University of Salerno, Via Giovanni Paolo II, Fisciano, SA, 84084, Italy.ORCID 0000-0003-1101-3248
Giulia PuliattiDepartment of Neuroscience, Università Cattolica del Sacro Cuore, Largo F. Vito 1, Rome, 00168, Italy.ORCID 0000-0002-9275-4576
Domenica Donatella Li PumaDepartment of Neuroscience, Università Cattolica del Sacro Cuore, Largo F. Vito 1, Rome, 00168, Italy.ORCID 0000-0001-6729-6967
Bruno BandieraDepartment of Neuroscience, Università Cattolica del Sacro Cuore, Largo F. Vito 1, Rome, 00168, Italy.ORCID 0000-0002-8311-7241
Beatrice CannataDepartment of Neuroscience, Università Cattolica del Sacro Cuore, Largo F. Vito 1, Rome, 00168, Italy.ORCID 0009-0000-4158-0062
Maria Elena MarcocciDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome, 00185, Italy.ORCID 0000-0003-4751-4263
Nicolina CastagnoDepartment of Chemistry and Biology "Adolfo Zambelli", University of Salerno, Via Giovanni Paolo II, Fisciano, SA, 84084, Italy.
Irene ContentoDepartment of Chemistry and Biology "Adolfo Zambelli", University of Salerno, Via Giovanni Paolo II, Fisciano, SA, 84084, Italy.
Salvatore ImpembaDepartment of Chemistry and Biology "Adolfo Zambelli", University of Salerno, Via Giovanni Paolo II, Fisciano, SA, 84084, Italy.ORCID 0009-0005-3644-357X
Mariarosa ScognamiglioDepartment of Industrial Engineering, University of Salerno, Via Giovanni Paolo II, Fisciano, SA, 84084, Italy.ORCID 0000-0002-1923-6844
Rocco Di GirolamoDepartment of Chemical Sciences, University of Naples Federico II, Via Cintia, 21, Naples, 80126, Italy.ORCID 0000-0001-8815-2997
Vincenzo NaddeoDepartment of Civil Engineering, University of Salerno, Via Giovanni Paolo II, Fisciano, SA, 84084, Italy.ORCID 0000-0002-3395-3276
Patrizia CantonDepartment of Molecular Sciences and Nanosystems, University Ca' Foscari Venezia, Dorsoduro 3246, Venezia, 30123, Italy.ORCID 0000-0003-1604-5265
Carmine CapacchioneDepartment of Chemistry and Biology "Adolfo Zambelli", University of Salerno, Via Giovanni Paolo II, Fisciano, SA, 84084, Italy.ORCID 0000-0001-7254-8620
Laura SpositoDepartment of Neuroscience, Università Cattolica del Sacro Cuore, Largo F. Vito 1, Rome, 00168, Italy.
Martina AlbiniDepartment of Neuroscience, Università Cattolica del Sacro Cuore, Largo F. Vito 1, Rome, 00168, Italy.ORCID 0000-0001-5671-2742
Francesco PastoreDepartment of Neuroscience, Università Cattolica del Sacro Cuore, Largo F. Vito 1, Rome, 00168, Italy.
Silvia BaroniFondazione Policlinico Universitario A. Gemelli, IRCCS, Largo A. Gemelli 8, Rome, 00168, Italy.
Alfonso GrassiDepartment of Chemistry and Biology "Adolfo Zambelli", University of Salerno, Via Giovanni Paolo II, Fisciano, SA, 84084, Italy.ORCID 0000-0002-2664-3114
Claudio GrassiDepartment of Neuroscience, Università Cattolica del Sacro Cuore, Largo F. Vito 1, Rome, 00168, Italy.ORCID 0000-0001-7253-1685
Roberto PiacentiniDepartment of Neuroscience, Università Cattolica del Sacro Cuore, Largo F. Vito 1, Rome, 00168, Italy.ORCID 0000-0003-4215-1643

Funding

Alzheimer's Association Research 24AARG-1193678Finanziato dall'Unione europea-Next Generation EU, Missione 4, Componente 1-CUP D53D23017260001Ministero dell'Università e della Ricerca - MUR PRIN-PNRR-2022Università degli Studi di Salerno FARB ORSA224812Università degli Studi di Salerno FARB ORSA239513Università degli Studi di Salerno FARB ORSA247407
6 · The paper itself

Abstract

"A Trojan Horse for Lithium Delivery". Lithium has important pharmacological applications, although its use is severely limited due to its narrow therapeutic window of administrable concentrations. This study presents a novel nanocarrier for this metal cation based on glutathione-stabilized gold nanoparticles (LiG-AuNPs), which enable targeted release of lithium. LiG-AuNPs are easily synthesized, with dimensions of ≈2 nm, with a lithium loading of 2 wt%. These particles show a tendency to aggregate and a narrow size distribution. Aggregates of LiG-AuNPs (a-LiG-AuNPs) are non-toxic to cells at concentrations lower than 2 mg mL

Indexed as

Drug CarriersGlycogen Synthase Kinase 3GoldLithiumMetal NanoparticlesAnimalsGlutathioneGlycogen Synthase Kinase 3 betaHumansMaleMicePhosphorylationDrug CarriersGlutathioneGlycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaGoldLithiumAlzheimer's diseasebipolar disorderglycogen synthase kinase 3gold nanoparticleHSV‐1 infectionlithium

Identifiers

PMID41020548
PMCPMC12801361

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.