ArticleJornal brasileiro de nefrologia
Influence of albumin and phase angle on the survival of patients with chronic kidney disease on hemodialysis: a prospective study.
Article in Jornal brasileiro de nefrologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Lean tissue mass is associated with adverse outcomes across different stages of chronic kidney disease: a systematic review and meta-analysis.Scientific reports · 2026Pooled it
- Effect of probiotic and synbiotic administration on the nutritional status of hemodialysis patients: a randomized-controlled trial.International urology and nephrology · 2026Trial
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Authors and funding
8 authors.
Funding
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Abstract
introductionHemodialysis (HD) prolongs the survival of patients with end-stage chronic kidney disease (CKD), but mortality remains high due to malnutrition and inflammation. This study aimed to investigate whether low albumin levels and a reduced phase angle (PA) predict higher mortality in HD patients.
methodsThis prospective cohort study followed 82 HD patients for 36 months. Biological markers, including albumin and oxidative stress indicators, were measured before and after a single HD session upon study enrollment (time zero). PA was determined by bioimpedance analysis. Kaplan-Meier survival curves and Cox regression analyses were performed to assess the association between albumin, PA, and mortality.
resultsPatients with PA <4 had a mean survival of 11.6 months, compared to 27.0 months for those with PA ≥ 4 (HR = 5.66; 95% CI: 2.44-13.12). Similarly, patients with albumin <3.9 g/dL had significantly lower survival rates at 6, 12, and 36 months compared to those with albumin ≥3.9 g/dL (HR = 4.39; 95% CI: 1.81-10.63).
conclusionLow albumin levels and a reduced PA are strong predictors of mortality in HD patients. Routine monitoring and targeted interventions to improve these markers could enhance survival outcomes.
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