Evidence map›Paper›PMID 41020455›Full record

Trial reportMedical decision making : an international journal of the Society for Medical Decision Making2026

Effects of Prior Diagnosis on Second Opinions and Pathologist Viewing Behaviors: Results from a Randomized Trial in Breast Pathology.

Kathleen F Kerr, Megan M Eguchi, Hannah Shucard, Trafton Drew, Donald L Weaver, Joann G Elmore, Tad T Brunyé

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Medical decision making : an international journal of the Society for Medical Decision Making, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kathleen F KerrDepartment of Biostatistics, University of Washington, Seattle, WA, USA.ORCID 0000-0002-6438-9583
Megan M EguchiDavid Geffen School of Medicine, Department of Medicine, University of California, Los Angeles.
Hannah ShucardDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Trafton DrewSirona Medical, San Francisco, CA, USA.
Donald L WeaverDepartment of Pathology, University of Vermont Larner College of Medicine and Vermont Cancer Center, Burlington, VT, USA.
Joann G ElmoreDavid Geffen School of Medicine, Department of Medicine, University of California, Los Angeles.ORCID 0000-0002-7311-6835
Tad T BrunyéCenter for Applied Brain and Cognitive Sciences, Tufts University, Medford, MA, USA.ORCID 0000-0002-8788-8764

Funding

Accuracy of Breast Pathology and the Impact of Double ReadingR01CA140560 · NCI · UNIVERSITY OF WASHINGTON · PI ELMORE, JOANN G, WEAVER, DONALD LEE · 2009 to 2013
$3.3M
Reader Accuracy in Pathology Interpretation and Diagnosis: Perception and Cognition (RAPID-PC)R01CA225585 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ELMORE, JOANN G, WEAVER, DONALD LEE · 2018 to 2022
$3.2M
Digital Pathology_Accuracy Viewing Behavior and Image CharacterizationR01CA172343 · NCI · UNIVERSITY OF WASHINGTON · PI SHAPIRO, LINDA, WEAVER, DONALD LEE · 2013 to 2017
$3.2M
NCI NIH HHS R01 CA140560NCI NIH HHS R01 CA172343NCI NIH HHS R01 CA225585
6 · The paper itself

Abstract

ObjectiveTo study the effects of exposure to a prior diagnosis (PD) on second opinions in breast pathology.Materials and MethodsPathologists interpreted digital breast biopsy cases in 2 phases separated by a washout. Phase 2 interpretations were randomly assigned to PD or no PD. When presented, PD was always more or less severe than a participant's phase 1 diagnosis. Viewing behaviors, including zoom level, were recorded during all interpretations. Twenty pathologists yielded 556 interpretations of 32 different cases.ResultsPathologists were 71% more likely to give a less severe diagnosis when exposed to a less severe PD than with no PD (RR 1.71, 95% CI 1.33-2.20,

Indexed as

BreastBreast NeoplasmsPathologistsReferral and ConsultationAdultFemaleHumansMiddle Agedbreast cancereye trackingmedical image perceptionpathologysecond opinions

Identifiers

PMID41020455
PMCPMC12731604

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.