Evidence map›Paper›PMID 41020354›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2025

Physicochemical Necessary and Sufficient Conditions for Superferromagnetism in High-Resolution Magnetic Particle Imaging.

Chinmoy Saayujya, Benjamin Fellows, Yifeng Shi, Ruhani Sagar, Benjamin G Cary, Jacob Bryan, Cherilyn Yu, Melissa Kim, Allison Hartley, Quincy Huynh and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Chinmoy SaayujyaDepartment of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA, 94720, USA.ORCID https://orcid.org/0000-0001-6125-8986
Benjamin FellowsMagnetic Insight, Inc., Alameda, CA, 94502, USA.ORCID https://orcid.org/0000-0002-8404-7281
Yifeng ShiDepartment of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA, 94720, USA.
Ruhani SagarDepartment of Materials Science and Engineering, University of California, Berkeley, CA, 94720, USA.ORCID https://orcid.org/0000-0001-7935-8782
Benjamin G CaryDepartment of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA, 94720, USA.ORCID https://orcid.org/0000-0002-2389-9173
Jacob BryanDepartment of Bioengineering, University of California, Berkeley, CA, 94720, USA.
Cherilyn YuDepartment of Bioengineering, University of California, Berkeley, CA, 94720, USA.
Melissa KimDepartment of Bioengineering, University of California, Berkeley, CA, 94720, USA.
Allison HartleyDepartment of Bioengineering, University of California, Berkeley, CA, 94720, USA.ORCID https://orcid.org/0009-0005-7919-2790
Quincy HuynhDepartment of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA, 94720, USA.ORCID https://orcid.org/0000-0002-6725-3999
Prashant ChandrasekharanDepartment of Bioengineering, University of California, Berkeley, CA, 94720, USA.ORCID https://orcid.org/0000-0002-6139-1979
Zhi Wei TayNational Institute of Advanced Industrial Science and Technology, Ibaraki, 305-8564, Japan.ORCID https://orcid.org/0000-0002-2717-0515
Michael F WendlandDepartment of Bioengineering, University of California, Berkeley, CA, 94720, USA.
Steven M ConollyDepartment of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA, 94720, USA.ORCID https://orcid.org/0000-0002-3310-6085

Funding

Ten-Fold Resolution Boost for Magnetic Particle Imaging with Applications to Rapid, Non-Invasive Imaging of CAR-T Cell Therapies, Stroke, GI Bleeds and Pulmonary EmbolismsU01EB034694 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI STEVEN M CONOLLY · 2023 to 2026
$2.7M
In Vivo Therapeutic Cell Tracking by Advanced Magnetic Particle ImagingR01EB024578 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI CONOLLY, STEVEN M · 2017 to 2020
$2.2M
Stem Cell Engineering Training ProgramT32GM098218 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HEALY, KEVIN EDWARD, SCHAFFER, DAVID V · 2011 to 2020
$1.8M
Color MPI as a novel method for in vivo assessment of magnetic nanoparticle dynamics and bindingR44EB029877 · NIBIB · MAGNETIC INSIGHT, INC. · PI GOODWILL, PATRICK · 2020 to 2021
$1.6M
Magnetic Particle Imaging for High-Resolution Functional Brain ImagingR01EB029822 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI CONOLLY, STEVEN M · 2020 to 2020
$815k
Barbara and Gerson Bakar Foundation Bakar FellowshipM. Cook ChairNational Science Foundation Graduate Research Fellowship ProgramNIBIB NIH HHS R01 EB024578NIBIB NIH HHS R01 EB029822NIBIB NIH HHS R44 EB029877NIBIB NIH HHS U01 EB034694NIGMS NIH HHS T32 GM098218NIH HHS R01 EB024578NIH HHS R01EB029822NIH HHS R44 EB029877NIH HHS T32 GM098218NIH HHS U01 EB034694
6 · The paper itself

Abstract

Magnetic Particle Imaging (MPI) is a novel tracer modality that images the spatial distribution of superparamagnetic iron oxide nanoparticles (SPIOs) by exploiting their nonlinear response to magnetic fields. MPI image resolution is primarily influenced by the strength of the MPI gradient field and the physical and magnetic properties of the nanoparticle tracers. Although MPI offers exceptional sensitivity, contrast, and penetration depth, its spatial resolution remains limited, particularly in clinical systems due to safety limits on gradient field strength. Consequently, efforts to improve resolution focus on developing MPI-tailored tracers with enhanced magnetic resolution. This work explores the effects of strong dipole-dipole coupling between SPIOs in linear chain-like structures. This leads to the observation of superferromagnetism, a phenomenon in which assemblies of superparamagnetic nanoparticles exhibit transient magnetic behavior similar to ferromagnetism. This transition is associated with order-of-magnitude improvements in resolution and sensitivity. The influlence of these interactions on the magnetization curve is analyzed using a positive feedback model, and experimental observations such as coercivity are successfully predicted. The necessary conditions for the observation of superferromagnetism suggested by the theory are also experimentally validated. The positive feedback model is found to be an indispensable tool for the synthesis of high-resolution MPI tracers, optimizing core size, oxidation state, and coating.

Indexed as

magnetic particle imagingresolutionsuperferromagnetism

Identifiers

PMID41020354
PMCPMC12590522

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.