Evidence map›Paper›PMID 41020267›Full record

ArticleMolecular therapy. Methods & clinical development2025

Variation of VP2 stoichiometry and deamidation of VP1 during production and their impacts on the transduction efficiency of AAV vectors.

Takahiro Maruno, Mitsuko Fukuhara, Yasuo Tsunaka, Aoba Matsushita, Kiichi Hirohata, Karin Bandoh, Megumi Onaka, Risa Shibuya, Yuki Yamaguchi, Haruka Nishiumi and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Takahiro MarunoU-Medico Inc., 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Mitsuko FukuharaU-Medico Inc., 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Yasuo TsunakaGraduate School of Engineering, The University of Osaka, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Aoba MatsushitaGraduate School of Engineering, The University of Osaka, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Kiichi HirohataGraduate School of Engineering, The University of Osaka, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Karin BandohGraduate School of Engineering, The University of Osaka, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Megumi OnakaU-Medico Inc., 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Risa ShibuyaGraduate School of Engineering, The University of Osaka, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Yuki YamaguchiGraduate School of Engineering, The University of Osaka, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Haruka NishiumiGraduate School of Engineering, The University of Osaka, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Yoshiki NagashimaThermo Fisher Scientific, 3-9 Moriya-cho, Kanagawa-ku, Yokohama, Kanagawa 221-0022, Japan.
Daisuke HigoThermo Fisher Scientific, 3-9 Moriya-cho, Kanagawa-ku, Yokohama, Kanagawa 221-0022, Japan.
Toshie KuwaharaGraduate School of Engineering, The University of Osaka, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Tomoko UenoGraduate School of Engineering, The University of Osaka, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Masaharu MaedaOsaka Consolidated Laboratory, Manufacturing Technology Association of Biologics, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Guirong Kanai-BaiGraduate School of Engineering, The University of Osaka, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Noriko Yamano-AdachiGraduate School of Engineering, The University of Osaka, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Tetsuo TorisuGraduate School of Engineering, The University of Osaka, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Takeshi OmasaGraduate School of Engineering, The University of Osaka, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Susumu UchiyamaGraduate School of Engineering, The University of Osaka, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recombinant adeno-associated viruses (rAAVs) are a leading platform for

Indexed as

AAV vectoradeno-associated virus vectordeamidationgene therapyphysicochemical propertiestransduction efficiencyvector manufacturingviral protein stoichiometry

Identifiers

PMID41020267
PMCPMC12475848

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.