Evidence map›Paper›PMID 41020266›Full record

ArticleMolecular therapy. Methods & clinical development2025

Adeno-associated viral vector resource for the RNA-targeting Cas13d: A comparison of high-fidelity variants, DjCas13d and hfCas13d.

Franklin Back, Alfredo Sandoval, Lily M Vu, Veronica M Hong, Amulya Bhaskara, Sierra R Rodriguez, John T O'Brien, Benedict J Kolber, Sven Kroener, Jonathan E Ploski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Franklin BackDepartment of Neuroscience and Experimental Therapeutics, Penn State College of Medicine, Hershey, PA 17033-0850, USA.
Alfredo SandovalThe University of Texas Medical Branch, Galveston, TX 77555, USA.
Lily M VuDepartment of Neuroscience, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX 75080, USA.
Veronica M HongDepartment of Neuroscience, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX 75080, USA.
Amulya BhaskaraDepartment of Neuroscience, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX 75080, USA.
Sierra R RodriguezDepartment of Neuroscience, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX 75080, USA.
John T O'BrienDepartment of Neuroscience, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX 75080, USA.
Benedict J KolberDepartment of Neuroscience, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX 75080, USA.
Sven KroenerDepartment of Neuroscience, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX 75080, USA.
Jonathan E PloskiDepartment of Neuroscience and Experimental Therapeutics, Penn State College of Medicine, Hershey, PA 17033-0850, USA.

Funding

Vagus nerve stimulation modulates synaptic plasticity in the rat prefrontal cortex during the extinction of drug-seekingR01DA055008 · NIDA · UNIVERSITY OF TEXAS DALLAS · PI SVEN KROENER · 2022 to 2026
$2.0M
NIDA NIH HHS R01 DA055008
6 · The paper itself

Abstract

RNA-targeting CRISPR-Cas systems have emerged as alternatives to RNA-interference technology to knock down specific RNA transcripts. In particular, Cas13d derived from

Indexed as

AAVCas13CasRxcollateral-cleavageCRISPR/Cashighly-expressed transcriptsprotein expressionRfxCas13dRNA degradationtranscriptome changes

Identifiers

PMID41020266
PMCPMC12466237

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.