Diagnostic prediction of neonatal hyperbilirubinemia combined with germinal matrix-intraventricular hemorrhage based on cranial ultrasound hemodynamics: a retrospective case-control study.

Objective: To study the diagnostic prediction of cranial ultrasound hemodynamics in children with neonatal hyperbilirubinemia combined with germinal matrix-intraventricular hemorrhage (GMH-IVH). Methods: We included 148 hyperbilirubinemic neonates who underwent cranial ultrasound to obtain hemodynamic parameter indexes, and constructed a nomogram visual prediction model through unifactorial and multifactorial analyses to study the role of cranial ultrasound hemodynamic parameters in the diagnostic prediction of neonatal hyperbilirubinemia combined with GMH-IVH. Results: A total of 148 patients eligible for enrollment were included in this study, of which 40 children developed GMH-IVH, with an incidence rate of 27.03%. Multifactorial logistic stepwise regression analysis showed that mothers suffering from gestational hypertension, total bilirubin ≥15 mg/dl, anterior cerebral artery third day to first day resistance index ratio of ≥1, and middle cerebral artery third day to first day resistance index ratio of ≥1 were the independent risk factors for the development of GMH-IVH in neonatal hyperbilirubinemic infants ( Conclusion: Craniocerebral ultrasound hemodynamics-related parameters combined with clinical features to construct a predictive model for early and effective prediction of the occurrence and prognosis of GMH-IVH in neonates with hyperbilirubinemia.