Evidence map›Paper›PMID 41020178›Full record

ArticleBrain communications2025

More than chronic pain: behavioural and psychosocial protective factors predict lower brain age in adults with/at risk of knee osteoarthritis over two years.

Jared J Tanner, Angela Mickle, Udell Holmes, Brittany Addison, Kenia Rangel, Cynthia Garvan, Roland Staud, Song Lai, David Redden, Burel R Goodin and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jared J TannerDepartment of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32610, USA.ORCID https://orcid.org/0000-0001-6821-0029
Angela MickleDepartment of Physical Medicine and Rehabilitation, University of Florida, Gainesville, FL 32610, USA.ORCID https://orcid.org/0000-0001-9175-5342
Udell HolmesDepartment of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32610, USA.
Brittany AddisonDepartment of Physical Medicine and Rehabilitation, University of Florida, Gainesville, FL 32610, USA.
Kenia RangelDepartment of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32610, USA.
Cynthia GarvanDepartment of Anesthesiology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Roland StaudDepartment of Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Song LaiDepartment of Radiation Oncology & CTSI Human Imaging Core, University of Florida, Gainesville, FL 32610, USA.
David ReddenDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Burel R GoodinDepartment of Anesthesiology, Washington University, St. Louis, MO 63110, USA.
Catherine C PriceDepartment of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32610, USA.
Roger B FillingimPain Research & Intervention Center of Excellence, University of Florida, Gainesville, FL 32610, USA.
Kimberly T SibilleDepartment of Physical Medicine and Rehabilitation, University of Florida, Gainesville, FL 32610, USA.

Funding

Ethnic Differences in Responses to Painful StimuliR37AG033906 · NIA · UNIVERSITY OF FLORIDA · PI FILLINGIM, ROGER B · 2014 to 2023
$12.9M
Health Disparities in Osteoarthritis: Biological Aging, Stress, and Pain - Modulation by Resilience FactorsR01AG054370 · NIA · UNIVERSITY OF FLORIDA · PI SIBILLE, KIMBERLY THERESA · 2016 to 2020
$3.4M
NIA NIH HHS R01 AG054370NIA NIH HHS R37 AG033906
6 · The paper itself

Abstract

The interplay between chronic musculoskeletal pain and brain ageing is complex. Studies employing machine learning models to assess relationships between brain age and chronic pain generally show that higher chronic pain severity associates with older brain age. Analyses to date have not considered individual and community-level socioenvironmental risk factors or behavioural/psychosocial protective factors as potential modifiers of cross-sectional and longitudinal brain age. This study aimed to elucidate the relationships between chronic pain, socioenvironmental risk, behavioural/psychosocial protective factors, and brain ageing. The sample comprised 197 adults (Men:Women = 68:129) from a prospective observational cohort study. Most individuals reported knee pain and were with/at risk of osteoarthritis. A subset of 128 participants (Men:Women = 41:87) completed a follow-up MRI session at 2 years and were included in the longitudinal analysis (Aim 2). Participants were 45-85 years of age and self-identified as non-Hispanic Black or non-Hispanic White. Data collected included demographics, health history, pain assessments, individual and community-level socioenvironmental factors (education, income, household size, marital and insurance status, and area deprivation index) coded as a summative socioenvironmental risk variable, and behavioural/psychosocial factors (tobacco use, waist circumference, optimism, positive and negative affect, perceived stress, perceived social support, sleep) coded as a summative behavioural/psychosocial protective factor variable. Structural MRI data were used to estimate brain age by applying a machine learning approach (DeepBrainNet). Cross-sectional analyses utilized regression and analysis of variance, while longitudinal analyses utilized a linear mixed model. Higher chronic pain stage and socioenvironmental risk are associated with an increased brain age gap (the difference between chronological age and predicted brain age). Participants who had higher socioenvironmental risk had brains that were about three years older than those of participants with lower risk. Having more behavioural/psychosocial protective factors correlated with a lower brain age gap; participants with higher behavioural/psychosocial protective factors had brains that were over three years younger than participants with fewer behavioural/psychosocial protective factors. Longitudinally, higher baseline behavioural/psychosocial protective factors are associated with lower brain age over the 2-year span, beyond the effects of chronic pain stage and socioenvironmental risk. Our findings show behavioural/psychosocial protective factors may counteract neurobiological ageing and help buffer the brain from chronic pain.

Indexed as

behavioural/psychosocial protective factorsbrain agechronic musculoskeletal painmachine learningsocioenvironmental risk

Identifiers

PMID41020178
PMCPMC12465110

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.