Evidence map›Paper›PMID 41020176›Full record

ArticleBrain communications2025

Hyperpolarized [1-

Aditya Jhajharia, Mitchell Moyer, Jemima Olu-Owotade, Darrian McAfee, Abubakr Eldirdiri, Joshua Rogers, Minjie Zhu, Ujwal Boddeti, Riccardo Serra, J Marc Simard and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Aditya JhajhariaDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Mitchell MoyerDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID https://orcid.org/0000-0002-7504-1435
Jemima Olu-OwotadeDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Darrian McAfeeDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID https://orcid.org/0000-0002-0643-0699
Abubakr EldirdiriDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Joshua RogersDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Minjie ZhuDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Ujwal BoddetiDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Riccardo SerraDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
J Marc SimardDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Volodymyr GerzanichDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Muznabanu BachaniDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Dirk MayerDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Alexander KsendzovskyDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Funding

Hyperpolarized MRI for Metabolic Imaging of Epileptic TissueR21NS139180 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI KSENDZOVSKY, ALEXANDER, MAYER, DIRK · 2024 to 2024
$428k
Metabolic imaging of hyperpolarized 13C pyruvate in polycystic kidney diseaseR21DK131357 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MAYER, DIRK · 2022 to 2023
$194k
NIDDK NIH HHS R21 DK131357NINDS NIH HHS R21 NS139180
6 · The paper itself

Abstract

Thirty percent of epilepsy patients have seizures despite best medical therapy. While epilepsy surgery has emerged as a promising treatment option for these patients, surgical outcomes vary considerably between patients and have not significantly improved over the years. These stagnant outcomes can be attributed to poor seizure onset zone and epileptic network localization with currently available tools. Lactate production is a well-known consequence of metabolic reprogramming and biomarker in epilepsy. Detection of lactate elevations using conventional magnetic resonance spectroscopy has been extensively studied as an effective tool to non-invasively detect epileptic brain tissue. However, this method suffers from poor spatial resolution, which limits its clinical utility in presurgical resection mapping. In this study, we explore the utility of a recently developed approach, magnetic resonance spectroscopy and spectroscopic imaging of hyperpolarized [1-

Indexed as

epilepsyhyperpolarized 13Clactatemagnetic resonance imagingspectroscopy

Identifiers

PMID41020176
PMCPMC12464677

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.