Evidence map›Paper›PMID 41020081›Full record

ReviewJournal of medicine and life2025

Diagnostic challenges of autism spectrum disorder in women without intellectual or language impairments: a narrative review.

Alexandra Dolfi, Cătălina Tudose

Abstract readReview
In one paragraph

Review in Journal of medicine and life, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alexandra DolfiProf. Dr. Alexandru Obregia, Psychiatry Hospital, Bucharest, Romania.
Cătălina TudoseDepartment of Psychiatry, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism Spectrum Disorder (ASD) in adult women without intellectual or language impairments is frequently under-recognized, due to subtler manifestations, greater use of compensatory social strategies, and reliance on diagnostic frameworks developed from male presentations. Diagnostic overshadowing, where autistic traits are misattributed to other psychiatric conditions, further delays accurate identification. This narrative review aims to critically evaluate recent evidence on the diagnostic challenges of ASD in adult women without intellectual or language impairments, assess the performance of widely used screening tools, and present recommendations for improving gender-sensitive diagnostic practices. A structured literature search was applied (PubMed, PsycINFO, Scopus; January 2010-July 2025; English language) targeting studies on females aged ≥18 years without intellectual or language impairment. Diagnostic accuracy, screening tools, camouflaging, misdiagnosis, and psychosocial outcomes were examined. Original research, meta-analyses, and systematic reviews were included, and a narrative synthesis approach was chosen due to study heterogeneity. Female-typical presentations often include subtle social-communication differences, context-specific restricted interests, and higher camouflage levels than males, which decrease the sensitivity of standard screening tools. Women are more likely to receive prior psychiatric diagnoses before ASD is recognized, contributing to mental health burdens and poorer functional outcomes. Current adult ASD screening tools have limited capacity to detect female phenotypes. Integrating camouflaging assessment, nuanced developmental histories, and updated, gender-inclusive screening instruments is essential to improving diagnostic equity.

Indexed as

Autism Spectrum DisorderAdultFemaleHumansADHD, Attention-Deficit Hyperactivity DisorderADI-R, Autism Diagnostic Interview-RevisedADOS-2, Autism Diagnostic Observation Schedule, Second EditionAQ, Autism QuotientAS, Asperger SyndromeASD, Autism Spectrum Disorderautism spectrum disorder (ASD)BASC-3, Behavior Assessment System for Children, Third EditionBPD, Borderline Personality DisorderCAT-Q, Camouflaging Autistic Traits Questionnairecognition disorders/diagnosisdelayed diagnosisDSM-5, Diagnostic and Statistical Manual of Mental Disorders, Fifth EditionDSM-5-TR, Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text RevisionDSM-III, Diagnostic and Statistical Manual of Mental Disorders, Third EditionDSM-III-R, Diagnostic and Statistical Manual of Mental Disorders, Third Edition RevisedDSM-IV, Diagnostic and Statistical Manual of Mental Disorders, Fourth EditionDSM-IV-TR, Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revisionfemale phenotypeGQ-ASC, Girls Questionnaire for Autism Spectrum ConditionHFA, High-Functioning Autismhigh-functioning autism (HFA)ICD, International Classification of Diseaseslanguage development disorder/diagnosisOCD, Obsessive-Compulsive DisorderPTSD, Post-Traumatic Stress DisorderRAADS-R, Ritvo Asperger and Autism Diagnostic Scale-RevisedSfA-F – Screening for Autism in FemalesSRS-2 – Social Responsiveness Scale, Second Edition

Identifiers

PMID41020081
PMCPMC12467426

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.