SynthesisFrontiers in pharmacology2025
The effect of intraperitoneal instillation of drugs on postoperative analgesia after laparoscopic cholecystectomy: a network meta-analysis.
Synthesis in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06632184 (Pilot Comparative Study on the Efficacy of Multimodal Management With Peritoneal Lavage Using Saline Solution Versus Saline Solution With Ondansetron in Laparoscopic Cholecystectomy), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pilot Comparative Study on the Efficacy of Multimodal Management With Peritoneal Lavage Using Saline Solution Versus Saline Solution With Ondansetron in Laparoscopic Cholecystectomy
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0 citing papers in PubMed.
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Authors and funding
4 authors.
Funding
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Abstract
Background: Postoperative pain is a critical factor contributing to delayed discharge and postoperative recovery after laparoscopic cholecystectomy (LC). Intraperitoneal instillation of analgesic agents has been proposed as a means to alleviate pain in patients undergoing LC. This study aimed to evaluate the efficacy of various drugs administered via intraperitoneal instillation for postoperative analgesia after LC using a network meta-analysis approach. Methods: A comprehensive search was conducted in PubMed, EMbase, Web of Science and Cochrane Library databases from inception to August, 2025. Randomized controlled trials (RCTs) investigating the effects of intraperitoneal instillation on post-LC analgesia were included. Two independent reviewers screened studies, extracted data, and assessed the risk of bias. A frequentist network meta-analysis was performed to estimate standardized mean differences (SMDs) and 95% confidence intervals (CIs). The surface under the cumulative ranking curve (SUCRA) was used to rank the interventions for each outcome. Results: Eleven RCTs comprising 667 patients were included. According to SUCRA values, bicarbonate (96.5%) ranked highest in reducing VAS scores at 24 h post-surgery. Acetazolamide (85.9%) was most effective at 12 h, MgSO Conclusion: Intraperitoneal instillation of bicarbonate, acetazolamide, MgSO
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