Evidence map›Paper›PMID 41019955›Full record

ArticleJournal of human immunity2025

Gut dysbiosis patterns in CVID patients with noninfectious complications observed in a germ-free mouse model through fecal microbiota transplantation.

Joud Hajjar, Anita Y Voigt, Margaret E Conner, Alton G Swennes, Stephanie Fowler, Chadi Calarge, Danielle D Mendonca, Dominique Armstrong, Chen-Yen Chang, Jolan E Walter and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of human immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Joud HajjarThe William T. Shearer Center for Human Immunobiology at Texas Children's Hospital, Houston, TX, USA.ORCID 0000-0003-4633-1043
Anita Y VoigtThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.ORCID 0000-0002-6794-0385
Margaret E ConnerDepartments of Molecular Virology and Microbiology & Education, Innovation and Technology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-7146-8159
Alton G SwennesOffice of Comparative Medicine and Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0002-2507-6103
Stephanie FowlerCenter for Comparative Medicine, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-0785-4274
Chadi CalargeMenninger Department of Psychiatry and Behavioral Sciences and Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-4368-1294
Danielle D MendoncaDepartment of Pediatrics, Section of Immunology, Allergy and Retrovirology, Baylor College of Medicine, Houston, TX, USA.ORCID 0009-0009-8417-2689
Dominique ArmstrongDepartment of Medicine, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-6669-0911
Chen-Yen ChangDepartment of Medicine, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-3943-3044
Jolan E WalterDivision of Allergy/Immunology in Department of Pediatrics, University of South Florida, Tampa, FL, USA.
Manish J ButteDepartments of Pediatrics and Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-4490-5595
Tor SavidgeDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-5716-5357
Julia OhThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.ORCID 0000-0002-5534-7023
Farrah KheradmandBiology of Inflammation Center, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-5343-103X
Joseph F PetrosinoAlkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-4046-6898

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9M
Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI James Versalovic · 2001 to 2026
$28.3M
BD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430k
NCI NIH HHS P30 CA125123NCRR NIH HHS S10 RR024574NIDDK NIH HHS P30 DK056338
6 · The paper itself

Abstract

Patients with common variable immunodeficiency (CVID) who develop noninfectious complications (NIC) have worse clinical outcomes than those with infections only (INF). While gut microbiome aberrations have been linked to NIC, reductionist animal models that accurately recapitulate CVID are lacking. Our aim in this study was to uncover potential microbiome roles in the development of NIC in CVID. We performed whole-genome shotgun sequencing on fecal samples from CVID patients with NIC, INF, and their household controls. We also performed fecal microbiota transplants from CVID patients to germ-free mice. We found potentially pathogenic microbes

Identifiers

PMID41019955
PMCPMC12462835

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.