Evidence map›Paper›PMID 41019916›Full record

ArticleLaryngoscope investigative otolaryngology2025

Comprehensive Genetic Analysis of

Takeshi Wakabayashi, Koichiro Wasano, Kohei Nakamura, Makoto Hosoya, Ryutaro Kawano, Reika Takamatsu, Masafumi Ueno, Marie N Shimanuki, Nobuyoshi Tsuzuki, Takanori Nishiyama and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Laryngoscope investigative otolaryngology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Comprehensive Genetic Analysis ofLaryngoscope investigative otolaryngology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Takeshi WakabayashiDepartment of Otorhinolaryngology, Head and Neck Surgery Keio University School of Medicine Tokyo Japan.
Koichiro WasanoDepartment of Otorhinolaryngology, Head and Neck Surgery Tokai University School of Medicine Isehara Kanagawa Japan.ORCID https://orcid.org/0000-0001-7335-3622
Kohei NakamuraGenomics Unit, Keio Cancer Center Keio University School of Medicine Tokyo Japan.
Makoto HosoyaDepartment of Otorhinolaryngology, Head and Neck Surgery Keio University School of Medicine Tokyo Japan.
Ryutaro KawanoGenomics Unit, Keio Cancer Center Keio University School of Medicine Tokyo Japan.
Reika TakamatsuGenomics Unit, Keio Cancer Center Keio University School of Medicine Tokyo Japan.
Masafumi UenoDepartment of Otorhinolaryngology, Head and Neck Surgery Keio University School of Medicine Tokyo Japan.
Marie N ShimanukiDepartment of Otorhinolaryngology, Head and Neck Surgery Keio University School of Medicine Tokyo Japan.
Nobuyoshi TsuzukiDepartment of Otorhinolaryngology, Head and Neck Surgery Keio University School of Medicine Tokyo Japan.
Takanori NishiyamaDepartment of Otorhinolaryngology, Head and Neck Surgery Keio University School of Medicine Tokyo Japan.ORCID https://orcid.org/0000-0002-7136-531X
Takenori AkiyamaDepartment of Neurosurgery Keio University School of Medicine Tokyo Japan.
Masahiro TodaDepartment of Neurosurgery Keio University School of Medicine Tokyo Japan.
Hiroshi NishiharaGenomics Unit, Keio Cancer Center Keio University School of Medicine Tokyo Japan.
Hiroyuki OzawaDepartment of Otorhinolaryngology, Head and Neck Surgery Keio University School of Medicine Tokyo Japan.
Naoki OishiDepartment of Otorhinolaryngology, Head and Neck Surgery Keio University School of Medicine Tokyo Japan.ORCID https://orcid.org/0000-0001-8204-9518

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To elucidate the genetic etiology of sporadic vestibular schwannomas (VSs) and investigate the correlation between Methods: Nineteen patients who underwent VS resection at our otorhinolaryngology or neurosurgery department between June 2020 and March 2022 were included in this study. Whole-exome sequencing (WES) was performed to detect somatic changes in Results: WES identified somatic alterations in both Conclusion: Comprehensive genetic analyses, including WES, methylation analysis, and MLPA, are essential for identifying Level of Evidence: 4.

Indexed as

clinical phenotypecomprehensive genetic analysisNF2somatic changesporadic vestibular schwannoma

Identifiers

PMID41019916
PMCPMC12475970

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.