Evidence map›Paper›PMID 41019872›Full record

ArticleClinical ophthalmology (Auckland, N.Z.)2025

Comparisons of Early Changes of Vascular Structure After Treatment with Faricimab and Aflibercept in Eyes with Macular Neovascularization by OCT Angiography.

Shinichiro Chujo, Hisashi Matsubara, Yoko Mase, Yukiko Muramoto, Kumiko Kato, Mineo Kondo

Abstract read
In one paragraph

Article in Clinical ophthalmology (Auckland, N.Z.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shinichiro ChujoDepartment of Ophthalmology, Mie University Graduate School of Medicine, Tsu, Mie, Japan.ORCID 0000-0002-0005-5410
Hisashi MatsubaraDepartment of Ophthalmology, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
Yoko MaseDepartment of Ophthalmology, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
Yukiko MuramotoDepartment of Ophthalmology, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
Kumiko KatoDepartment of Ophthalmology, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
Mineo KondoDepartment of Ophthalmology, Mie University Graduate School of Medicine, Tsu, Mie, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate whether Faricimab, which targets Ang-2, can reduce macular neovascularization (MNV) metrics on OCTA compared with Aflibercept in treatment-naïve nAMD. Methods: Among 34 eyes treated with Aflibercept, 12 eyes were included; among 31 eyes treated with Faricimab, 14 eyes were included. Vessel area (Va) and junction density (JD) were measured using AngioTool over a 3-month loading period. Results: In the Faricimab group, mean Va changed from 0.14 mm Conclusion: There were no significant structural changes in MNV with either drug over the short term. These findings suggest that vascular effects of Faricimab may require longer observation to become evident.

Indexed as

AfliberceptFaricimabNeovascular age-related macular degenerationOptical coherence tomography angiography

Identifiers

PMID41019872
PMCPMC12476195

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.