Evidence map›Paper›PMID 41019760›Full record

ArticleMedeniyet medical journal2025

Exploring the Link between DNA Hypermethylation and HPV in Salivary Gland Tumors.

Anzila Meer, Sarina Sulong, Anani Aila Mat Zin, Rohimah Mohamud, Norhafiza Mat Lazim

Abstract read
In one paragraph

Article in Medeniyet medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Epigenetic alterations in head and neck cancer: a brief update.Virchows Archiv : an international journal of pathology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anzila MeerUniversiti Sains Malaysia, School of Medical Sciences, Department of Otorhinolaryngology-Head and Neck Surgery, Health Campus, Kelantan, Malaysia.ORCID 0009-0005-3018-7421
Sarina SulongUniversiti Sains Malaysia, School of Medical Sciences, Human Genome Centre, Health Campus, Kelantan, Malaysia.ORCID 0000-0001-5369-2707
Anani Aila Mat ZinUniversiti Sains Malaysia, School of Medical Sciences, Department of Pathology, Health Campus, Kelantan, Malaysia.ORCID 0000-0001-8026-3078
Rohimah MohamudUniversiti Sains Malaysia, School of Medical Sciences, Department of Immunology, Health Campus, Kelantan, Malaysia.ORCID 0000-0002-2465-6421
Norhafiza Mat LazimUniversiti Sains Malaysia, School of Medical Sciences, Department of Otorhinolaryngology-Head and Neck Surgery, Health Campus, Kelantan, Malaysia.ORCID 0000-0002-2367-1814

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Salivary gland tumors (SGTs) pose considerable diagnostic and treatment challenges due to their heterogeneous nature, diverse histogenesis, and unpredictable clinical outcomes. Benign tumors exhibit a known recurrence rate, whereas malignant tumors are associated with a poor prognosis and a low recovery rate. Nonetheless, despite the growing body of research, there is insufficient evidence to establish a link between SGTs, human papilloma virus (HPV) infection, and the hypermethylation of tumor suppressor genes. The aim of this study is to elucidate the relationship between DNA hypermethylation and HPV in SGTs, elucidate the role of DNA hypermethylation in HPV-associated SGTs, thereby offering insights into novel diagnostic, and prognostic markers. As epigenetic alterations significantly contribute to the development of carcinogenesis, addressing these epigenetic alterations may help in early treatment plans and early detection of SGTs.

Indexed as

DNA hypermethylationepigeneticshuman papilloma virussalivary gland tumorstumor suppressor genes

Identifiers

PMID41019760
PMCPMC12478624

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.