ArticleFrontiers in chemistry2025
Deciphering structure-composition-efficacy transformation in processed Fuzi: an integrated SEM, XRD, metabolomics, and pharmacodynamics approach.
Article in Frontiers in chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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12 authors.
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Abstract
Background: Methods: An integrative analytical approach combining scanning electron microscopy (SEM), X-ray diffraction (XRD), metabolomics, and pharmacodynamic evaluation was employed to investigate the structural, compositional, and functional transformations during Fuzi processing. Results: SEM imaging and XRD data revealed that the morphological breakdown of starch granules varied according to processing technique. Metabolomics analysis based on mass spectrum identified 57 diterpenoid alkaloids, including 12 bioactive components, whose levels fluctuated across nine processing variants. Pharmacodynamic profiling revealed distinct efficacy-safety trade-offs across these variants, underscoring the pivotal role of processing methods in determining clinical risk profiles and therapeutic indices. Conclusion: This study elucidated the structure-composition-efficacy correlations in Fuzi processing, highlighting the relationship between starch reorganization, alkaloid modification, and therapeutic outcomes. These insights offer a mechanistic basis for refining traditional processing protocols, optimizing detoxification and therapeutic retention, and advancing standardization in herbal medicine.
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