ArticleFrontiers in chemistry2025
Isothermal signal amplification-mediated nanozyme capture on DNA tetrahedra for ultrasensitive amperometric immunoassay of Epstein-Barr virus latent membrane protein 1.
Article in Frontiers in chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The overexpression of latent membrane protein 1 (LMP-1), a key oncoprotein encoded by the Epstein-Barr virus (EBV), is closely associated with the development and progression of nasopharyngeal carcinoma (NPC), making it a valuable biomarker for early diagnosis and prognosis. Herein, we report a highly sensitive amperometric immunoassay method for LMP-1 detection based on the strand displacement amplification (SDA)-mediated capture of nanozyme on a DNA tetrahedron (TDN)-modified electrode. In detail, a sandwich immunoassay was carried out on a microplate, followed by sequential capture of streptavidin and biotin-labeled SP-HP, which then initiated SDA in the presence of a nicking enzyme and DNA polymerase. The resulting trigger DNA hybridized with TDN-anchored hairpin probes, exposing terminal digoxin moieties that captured anti-digoxin antibody modified AuPt alloy nanozymes. The nanozymes catalyzed the oxidation of TMB in the presence of H
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.