Evidence map›Paper›PMID 41019639›Full record

ArticlebioRxiv : the preprint server for biology2025

A Mammalian Genomic Signature Shaped by Single Nucleotide Variants Controlling Transcriptome Integrity and Diversity.

Jian Yang, Samuel Ogunsola, Jason Wong, Aydan Wang, Roby Joehanes, Daniel Levy, Shalini Sharma, Chunyu Liu, Jiuyong Xie

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jian Yang
Samuel Ogunsola
Jason Wong
Aydan Wang
Roby Joehanes
Daniel Levy
Shalini Sharma
Chunyu Liu
Jiuyong XieORCID 0000-0003-2909-1033

Funding

Trans-omic Analysis of Alcohol Consumption and its Relation to Cardiovascular DiseaseR01AA028263 · NIAAA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LIU, CHUNYU, MA, JIANTAO · 2021 to 2025
$2.6M
Mitochondrial DNA, Nuclear DNA Methylation, and Cardiometabolic Disease TraitsR01HL155569 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LIU, CHUNYU · 2021 to 2024
$2.4M
NHLBI NIH HHS R01 HL155569NIAAA NIH HHS R01 AA028263
6 · The paper itself

Abstract

Many functional features of mammalian genomic sequences remain poorly understood. Here, we identify a widely evolved genomic signature, G-tract-AG motifs consisting of guanine tracts closely upstream of AG dinucleotides, which is significantly associated with single-nucleotide variants (SNVs) identified in genome-wide association studies (GWAS), particularly within non-coding regions (NCRs). Approximately 9,000 such G-tracts within human genes are disrupted by variants of the

Identifiers

PMID41019639
PMCPMC12466777

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.