Evidence map›Paper›PMID 41019636›Full record

ArticlebioRxiv : the preprint server for biology2025

Imaging progenitor cell differentiation during central nervous system remyelination using an MRI gene reporter.

Eliane E S Brechbühl, Myfanwy F E Hill, Civia Z Chen, Hallie F Gaitsch, Susana Ros, Luca Porcu, Alan J Wright, Daniel S Reich, Robin J M Franklin, Kevin M Brindle

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Eliane E S BrechbühlCancer Research UK, Cambridge Institute, University of Cambridge, UK.
Myfanwy F E HillWellcome-MRC Cambridge Stem Cell Institute and Department of Clinical Neurosciences, University of Cambridge, UK.
Civia Z ChenWellcome-MRC Cambridge Stem Cell Institute and Department of Clinical Neurosciences, University of Cambridge, UK.
Hallie F GaitschWellcome-MRC Cambridge Stem Cell Institute and Department of Clinical Neurosciences, University of Cambridge, UK.
Susana RosCancer Research UK, Cambridge Institute, University of Cambridge, UK.
Luca PorcuCancer Research UK, Cambridge Institute, University of Cambridge, UK.
Alan J WrightCancer Research UK, Cambridge Institute, University of Cambridge, UK.
Daniel S ReichTranslational Neuroradiology Section, NINDS, NIH, Bethesda, Maryland, USA.
Robin J M FranklinWellcome-MRC Cambridge Stem Cell Institute and Department of Clinical Neurosciences, University of Cambridge, UK.
Kevin M BrindleCancer Research UK, Cambridge Institute, University of Cambridge, UK.

Funding

Wellcome Trust
6 · The paper itself

Abstract

Demyelination, the loss of the myelin sheath from around otherwise intact axons, occurs in several diseases, most notably multiple sclerosis (MS). Demyelinated axons that are not remyelinated are vulnerable to irreversible degeneration and therefore therapies that enhance remyelination have been sought. However, there remains a paucity of suitable outcome measures to assess their efficacy. Magnetic Resonance Imaging (MRI) is a non-invasive imaging modality that is used both preclinically and clinically for the assessment of anatomy and tissue function. Here we describe an MRI technique for following the differentiation of oligodendrocyte progenitor cells (OPCs) into oligodendrocytes during the spontaneous regenerative process of remyelination

Identifiers

PMID41019636
PMCPMC12466776

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.