Evidence map›Paper›PMID 41019590›Full record

ArticleBioactive materials2025

Snake-fangs-bioinspired intelligently-responsive two-stage AIE gen-containing microneedle-based platform for integrated photodynamic infected-wound management and visual therapeutic diagnosis.

Lijuan Chen, Xiaomin Luo, Hao Yang, Ying Liu, Jiamin Zhang, Qian Zhang, Fengqian Yang, Xinhua Liu, Huie Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lijuan ChenKey Laboratory of Auxiliary Chemistry and Technology for Chemical Industry, Ministry of Education, Shaanxi University of Science and Technology, Xi'an, 710021, PR China.
Xiaomin LuoKey Laboratory of Auxiliary Chemistry and Technology for Chemical Industry, Ministry of Education, Shaanxi University of Science and Technology, Xi'an, 710021, PR China.
Hao YangKey Laboratory of Auxiliary Chemistry and Technology for Chemical Industry, Ministry of Education, Shaanxi University of Science and Technology, Xi'an, 710021, PR China.
Ying LiuKey Laboratory of Auxiliary Chemistry and Technology for Chemical Industry, Ministry of Education, Shaanxi University of Science and Technology, Xi'an, 710021, PR China.
Jiamin ZhangKey Laboratory of Auxiliary Chemistry and Technology for Chemical Industry, Ministry of Education, Shaanxi University of Science and Technology, Xi'an, 710021, PR China.
Qian ZhangCollege of Bioresources Chemistry and Materials Engineering, National Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi University of Science and Technology, Xi'an, 710021, PR China.
Fengqian YangCollege of Bioresources Chemistry and Materials Engineering, National Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi University of Science and Technology, Xi'an, 710021, PR China.
Xinhua LiuKey Laboratory of Auxiliary Chemistry and Technology for Chemical Industry, Ministry of Education, Shaanxi University of Science and Technology, Xi'an, 710021, PR China.
Huie JiangCollege of Bioresources Chemistry and Materials Engineering, National Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi University of Science and Technology, Xi'an, 710021, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The efficient treatment of prevalent drug-resistant (DR) bacteria-infected wounds caused by the clinical use of conventional antibiotics remains a significant challenge. Here, a well-integrated intelligent drug-releasing, photodynamic therapy, and visual therapeutic diagnosis strategy combining burgeoning aggregation-induced emission luminogen (AIE-gen) and microneedling technology is innovatively proposed for advanced infected-wound management. This strategy is based on an intelligently responsive two-stage AIE-gen-containing microneedle-based platform (AIE-film/TS-MN) with a double-layer structure. The uppermost layer comprises an on-demand pH-responsive AIE-photosensitizer (AFPP)-based film (AIE-film). This layer is designed to achieve the precise release of reactive oxygen species (ROS) or nitrocefin, which responds to

Indexed as

Aggregation-induced emissionBacterial infectionMicroneedlePhotodynamic therapyVisual monitoringWound healing

Identifiers

PMID41019590
PMCPMC12476076

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.